Spontaneous evolution patterns of focal congenital hepatic hemangiomas: a case series of 25 patients

Background Hepatic hemangiomas are the most common benign liver tumors of infancy. They are termed congenital if fully developed at birth or infantile if they appear in the first weeks of life. Previous studies suggested that most focal hepatic hemangiomas are congenital in nature, exhibit no postna...

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Bibliographic Details
Published in:Pediatric radiology 2022-05, Vol.52 (6), p.1048-1060
Main Authors: Rutten, Caroline, Ladarre, Delphine, Ackermann, Oanez, Gonzales, Emmanuel, Guettier, Catherine, Franchi-Abella, Stéphanie
Format: Article
Language:English
Subjects:
Age
Biomarkers
Computed tomography
Corticosteroids
Diagnosis
Embolization
Evolution
Glucose transporter
Hemangioma
Hemorrhage
Hepatic artery
Imaging
Lesions
Liver
Magnetic resonance imaging
Medical imaging
Medicine
Medicine & Public Health
Neuroradiology
Nuclear Medicine
Oncology
Original Article
Patients
Pediatrics
Prenatal diagnosis
Propranolol
Protein transport
Radiology
Tumors
Ultrasound
Volumetric analysis
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Summary:Background Hepatic hemangiomas are the most common benign liver tumors of infancy. They are termed congenital if fully developed at birth or infantile if they appear in the first weeks of life. Previous studies suggested that most focal hepatic hemangiomas are congenital in nature, exhibit no postnatal growth and have an evolution that parallels their cutaneous counterparts. They are subdivided by pattern of involution, whether rapidly involuting (RICH), partially involuting (PICH) or non-involuting (NICH) congenital hemangiomas. In our experience, some focal hepatic hemangiomas show postnatal growth, behaving like infantile forms. Objectives To analyze the spontaneous evolution of focal congenital hepatic hemangiomas with quantification of tumor volume changes over time and to identify initial postnatal ultrasound (US) imaging biomarkers predictive of their evolution pattern. Materials and methods A retrospective review of clinical, imaging and pathology data of children diagnosed with focal congenital hepatic hemangioma (prenatal diagnosis or age at diagnosis
ISSN:0301-0449
1432-1998
DOI:10.1007/s00247-021-05277-4