Erythropoietin regulates signaling pathways associated with neuroprotective events

Erythropoietin is a cytokine that binds to the Erythropoietin receptor and regulates the formation of erythroid cells during erythropoiesis in the bone marrow. However, many other organs and tissues express Erythropoietin and its receptor, such as the Nervous System, which principally regulates tiss...

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Bibliographic Details
Published in:Experimental brain research 2022-05, Vol.240 (5), p.1303-1315
Main Authors: Sergio, Cornelio-Martínez, Rolando, Castañeda-Arellano
Format: Article
Language:English
Subjects:
AKT protein
Analysis
Astrocytes
Biomedical and Life Sciences
Biomedicine
Bone marrow
Cell survival
Cellular signal transduction
Central nervous system
Cytokines
Erythroid cells
Erythropoiesis
Erythropoietin
Erythropoietin - metabolism
Erythropoietin - pharmacology
Erythropoietin receptors
Humans
Nervous system
Neurology
Neurons
Neuroprotection
Neuroprotective Agents - pharmacology
Neuroprotective Agents - therapeutic use
Neurosciences
Receptors, Erythropoietin - metabolism
Review
Signal Transduction
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Summary:Erythropoietin is a cytokine that binds to the Erythropoietin receptor and regulates the formation of erythroid cells during erythropoiesis in the bone marrow. However, many other organs and tissues express Erythropoietin and its receptor, such as the Nervous System, which principally regulates tissue protection. In the Central Nervous System, Erythropoietin is principally expressed by astrocytes, while neurons mainly express Erythropoietin receptors. Moreover, Erythropoietin acts as a pleiotropic molecule with neuroprotective effects, and its mechanisms of signal transduction pathways are defined, and there is a growing interest in its therapeutic potential. This review focuses on the role of Erythropoietin and its relationship with HIF1, PI3/Akt, GSK3B, JAK/STAT, and MAPKs signaling pathways that leads to cell survival after injury in the Central Nervous System. Knowledge of these signaling systems comprehensively could better guide EPO treatment to restoring different SNC alterations mediated by different insults.
ISSN:0014-4819
1432-1106
DOI:10.1007/s00221-022-06331-9