Recent Progress of Cyanine Fluorophores for NIR‐II Sensing and Imaging

The cyanine fluorophores, a kind of classic organic fluorophores, are famous for their high extinction coefficient, simple synthetic route, and relatively long absorption and emission wavelengths. Moreover, the excellent biocompatibility and low toxicity in biological samples make cyanine fluorophor...

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Bibliographic Details
Published in:Chemistry, an Asian journal an Asian journal, 2022-04, Vol.17 (8), p.e202200147-n/a
Main Authors: Zhou, Hui‐Jie, Ren, Tian‐Bing
Format: Article
Language:English
Subjects:
Biocompatibility
Biological properties
Chemical compounds
Chemistry
cyanine fluorophores
Fluorescence
Fluorescent Dyes
fluorescent probe
Imaging
Near infrared radiation
NIR-II imaging
NIR-II sensing
Optical Imaging - methods
Quinolines
Spectroscopy, Near-Infrared - methods
Toxicity
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Summary:The cyanine fluorophores, a kind of classic organic fluorophores, are famous for their high extinction coefficient, simple synthetic route, and relatively long absorption and emission wavelengths. Moreover, the excellent biocompatibility and low toxicity in biological samples make cyanine fluorophores show excellent application value in the biomedical field, especially in Near‐Infrared II (NIR‐II) sensing and imaging. In this review, we briefly outline the history, characteristics, and current state of development of cyanine fluorophores. In particular, we described the application of cyanine fluorophores in NIR‐II sensing and imaging. We hope this review can help researchers grab the latest information in the fast‐growing field of cyanine fluorophores for NIR‐II sensing and imaging. Cyanine dye‐based NIR‐II fluorescent probes, owing to their high extinction coefficient and simple synthetic procedure, are highly useful for deep‐tissue high‐contrast imaging in vivo. In this review, we briefly outlined the history of the cyanine, summarized the chemical structures of recently developed NIR‐II cyanine dyes, and highlighted their biomedical applications in NIR‐II sensing and imaging.
ISSN:1861-4728
1861-471X
DOI:10.1002/asia.202200147