Microbial analysis of endodontic infections in teeth with post‐treatment apical periodontitis before and after medication

This study aimed to determine the intraradicular microbiota of previously root canal‐treated teeth with apical periodontitis and to investigate the antibacterial effectiveness of different intracanal medicaments. Sixteen patients with post‐treatment apical periodontitis were allocated into two group...

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Bibliographic Details
Published in:Australian endodontic journal 2023-04, Vol.49 (1), p.75-86
Main Authors: Ersahan, Seyda, Hepsenoglu, Yelda Erdem
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Bacteria
Calcium hydroxide
Calcium Hydroxide - therapeutic use
chemomechanical preparation
Chlorhexidine
Chlorhexidine - therapeutic use
Copy number
Dental Pulp Cavity - microbiology
droplet digital
Endodontics
Enterococcus faecalis
Gum disease
Humans
intracanal medicaments
microbiology
Microbiota
Periapical Periodontitis - drug therapy
Periodontitis
post‐treatment apical periodontitis
Root Canal Irrigants - therapeutic use
Root Canal Therapy
Root canals
Teeth
total bacterial load
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Summary:This study aimed to determine the intraradicular microbiota of previously root canal‐treated teeth with apical periodontitis and to investigate the antibacterial effectiveness of different intracanal medicaments. Sixteen patients with post‐treatment apical periodontitis were allocated into two groups according to the intracanal medicament used: calcium hydroxide (CH) and 2% chlorhexidine gluconate gel (CHX) group. Total bacterial loads, as well as the amount of Enterococcus faecalis (E. faecalis) were determined before (S1) and after (S2) chemomechanical preparation and finally, after intracanal medication (S3) by means of ddPCR. The unpaired t test was used to compare parametric. S3‐total bacteria copy number of the CH group was lower than the CHX group (p  0.05). But in terms of total bacteria, CH is better than CHX. Consequently, CH can be used to optimise the antibacterial efficiency of chemomechanical preparation in previously root canal‐treated teeth with apical periodontitis.
ISSN:1329-1947
1747-4477
DOI:10.1111/aej.12613