Does prolonged cold ischemia affect outcomes in donation after cardiac death donor kidney transplants?

Background The purpose of this study was to analyze the combined effect of cold ischemia time (CIT) and donation after cardiac death (DCD, with requisite warm ischemia time, WIT) on kidney transplant (KT) outcomes. Methods Single center retrospective review of DCD KT recipients stratified by CIT. Re...

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Bibliographic Details
Published in:Clinical transplantation 2022-06, Vol.36 (6), p.e14628-n/a
Main Authors: Harriman, David I., Kazakov, Herman, Rogers, Jeffrey, Farney, Alan C., Orlando, Giuseppe, Jay, Colleen, Reeves‐Daniel, Amber, Stratta, Robert J.
Format: Article
Language:English
Subjects:
Cold Ischemia
Death
delayed graft function
Delayed Graft Function - etiology
donation after cardiac death
Graft Rejection - etiology
Graft Survival
Humans
Kidney Transplantation - adverse effects
patient survival
primary nonfunction
Retrospective Studies
Risk Factors
Tissue Donors
warm ischemia
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Summary:Background The purpose of this study was to analyze the combined effect of cold ischemia time (CIT) and donation after cardiac death (DCD, with requisite warm ischemia time, WIT) on kidney transplant (KT) outcomes. Methods Single center retrospective review of DCD KT recipients stratified by CIT. Results From 6/08 to 10/20, we performed 446 DCD KTs (115 CIT ≤20, 205 CIT 20–30, 88 CIT 30–40, 38 CIT ≥40 h). Mean WITs (26/25/27/23 min) and KDPI values (59%/55%/55%/59%) were similar while mean CITs (16.4/23.6/33.4/42.5 h) and pump times (10.3/13.6/16.1/20.4 h) differed across groups (P 
ISSN:0902-0063
1399-0012
DOI:10.1111/ctr.14628