Tumor-infiltrating lymphocytes (TILs)/volume and prognosis: The value of TILs for survival in HER2 and TN breast cancer patients treated with chemotherapy

The use of the tumor microenvironment as a target in creating treatment modalities and as a biomarker in predicting treatment response has become increasingly important. Tumor-infiltrating lymphocytes (TILs), located in the tumor microenvironment, are the fundamental elements of the specific immunol...

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Bibliographic Details
Published in:Annals of diagnostic pathology 2022-06, Vol.58, p.151930-151930, Article 151930
Main Authors: Okcu, Oğuzhan, Öztürk, Seda Duman, Öztürk, Çiğdem, Şen, Bayram, Yasin, Ayşe İrem, Bedir, Recep
Format: Article
Language:English
Subjects:
Breast
Prognosis
Tumor-infiltrating lymphocyte
Tumor-infiltrating lymphocyte volume
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Summary:The use of the tumor microenvironment as a target in creating treatment modalities and as a biomarker in predicting treatment response has become increasingly important. Tumor-infiltrating lymphocytes (TILs), located in the tumor microenvironment, are the fundamental elements of the specific immunological response against tumor cells and have prognostic importance in many types of cancer. Between January 2010 and June 2021, 350 patients who were operated on in our hospital and met the study criteria were included in the study. TILs and tumor-infiltrating lymphocyte volume (TILV) were evaluated in hematoxylin-eosin sections of the patients. Presence of high stromal TILs was associated with improved survival (p = 0.036), distant metastasis (p = 0.009), high nuclear and histological grade (p 
ISSN:1092-9134
1532-8198
DOI:10.1016/j.anndiagpath.2022.151930