Tumour characteristics of screen-detected and interval cancers in the Flemish Breast Cancer Screening Programme: A mammographic breast density study

•In an organized mammography screening programme interval cancers have a worse prognostic tumour profile than screen-detected cancers.•Analysis of molecular subtype distributions versus breast density reveals a higher percentage of the triple-negative phenotype in low-density breasts.•The observatio...

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Bibliographic Details
Published in:Maturitas 2022-04, Vol.158, p.55-60
Main Authors: Timmermans, Lore, De Brabander, Isabel, Van Damme, Nancy, Bleyen, Luc, Martens, Patrick, Van Herck, Koen, Thierens, Hubert, Bacher, Klaus, Depypere, Herman
Format: Article
Language:English
Subjects:
Breast cancer
Breast Density
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
Early Detection of Cancer
Female
Humans
Interval cancer
Mammography - methods
Mass Screening - methods
Retrospective Studies
Screening mammography
Tumour characteristics
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Summary:•In an organized mammography screening programme interval cancers have a worse prognostic tumour profile than screen-detected cancers.•Analysis of molecular subtype distributions versus breast density reveals a higher percentage of the triple-negative phenotype in low-density breasts.•The observations support arguments against the prolongation of screening intervals in low-density breasts. The objective is to investigate tumour prognostic factors versus breast density in screen-detected cancers and interval cancers. The results may highlight the need for more personalised screening protocols based on breast density in organized screening programmes. A retrospective study was performed of tumour characteristics of screen-detected cancers (n=468) and interval cancers (n=515) of 983 women who participated in the Flemish Breast Cancer Screening Programme in 2009-2010. Breast density was obtained from the screening programme data. Information on nodal invasion and histological grading was taken from the Belgian Cancer Registry. Tumour size and proliferation and receptor expression status were retrieved from pathology reports. The differences in tumour characteristics between screen-detected and interval cancers as well as the variation in these variables with breast density in both groups were studied by logistic regression. A comparison of tumour characteristics between screen-detected cancers and interval cancers systematically showed features of more aggressive tumours in interval cancers: larger tumour size, nodal invasion, grade 3 tumours, and hormone receptor negative phenotype (p
ISSN:0378-5122
1873-4111
DOI:10.1016/j.maturitas.2021.12.006