The interaction between glycemic index, glycemic load, and the genetic variant ADIPOQ T45G (rs2241766) in the risk of colorectal cancer: a case–control study in a Korean population

Purpose The glycemic index (GI), glycemic load (GL), and adiponectin level contribute to glycemic response and insulin sensitivity in the body. Studies have shown that tumor development is related to glycemic disorders; however, the results are contradictory. We aimed to investigate the association...

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Bibliographic Details
Published in:European journal of nutrition 2022-08, Vol.61 (5), p.2601-2614
Main Authors: Lu, Y-Thanh, Gunathilake, Madhawa, Lee, Jeonghee, Oh, Jae Hwan, Chang, Hee Jin, Sohn, Dae Kyung, Shin, Aesun, Kim, Jeongseon
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - genetics
Blood Glucose
Cancer
Case-Control Studies
Chemistry
Chemistry and Materials Science
Colorectal cancer
Colorectal carcinoma
Diet
Dietary Carbohydrates
Genetic diversity
Genotype & phenotype
Genotypes
Glycemic Index
Glycemic Load
Health risks
Humans
Insulin
Mutation
Nutrient deficiency
Nutrition
Original Contribution
Population studies
Rectal Neoplasms
Rectum
Republic of Korea - epidemiology
Risk Factors
Tumors
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Summary:Purpose The glycemic index (GI), glycemic load (GL), and adiponectin level contribute to glycemic response and insulin sensitivity in the body. Studies have shown that tumor development is related to glycemic disorders; however, the results are contradictory. We aimed to investigate the association of GI and GL with colorectal cancer (CRC) risk in a Korean population and their possible interactions with the genetic variant ADIPOQ T45G. Methods and results A case–control study including 2096 participants with 695 CRC cases was conducted. The results showed that diets with high GI or GL were significantly associated with an increased risk of CRC [odds ratio (OR) = 5.44, 95% confidence interval (CI) 3.85–7.68; OR = 4.43, 95% CI 3.18–6.15, respectively; all p -trends 
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-022-02845-8