The interaction between glycemic index, glycemic load, and the genetic variant ADIPOQ T45G (rs2241766) in the risk of colorectal cancer: a case–control study in a Korean population

Purpose The glycemic index (GI), glycemic load (GL), and adiponectin level contribute to glycemic response and insulin sensitivity in the body. Studies have shown that tumor development is related to glycemic disorders; however, the results are contradictory. We aimed to investigate the association...

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Published in:European journal of nutrition 2022-08, Vol.61 (5), p.2601-2614
Main Authors: Lu, Y-Thanh, Gunathilake, Madhawa, Lee, Jeonghee, Oh, Jae Hwan, Chang, Hee Jin, Sohn, Dae Kyung, Shin, Aesun, Kim, Jeongseon
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - genetics
Blood Glucose
Cancer
Case-Control Studies
Chemistry
Chemistry and Materials Science
Colorectal cancer
Colorectal carcinoma
Diet
Dietary Carbohydrates
Genetic diversity
Genotype & phenotype
Genotypes
Glycemic Index
Glycemic Load
Health risks
Humans
Insulin
Mutation
Nutrient deficiency
Nutrition
Original Contribution
Population studies
Rectal Neoplasms
Rectum
Republic of Korea - epidemiology
Risk Factors
Tumors
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container_title European journal of nutrition
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creator Lu, Y-Thanh
Gunathilake, Madhawa
Lee, Jeonghee
Oh, Jae Hwan
Chang, Hee Jin
Sohn, Dae Kyung
Shin, Aesun
Kim, Jeongseon
description Purpose The glycemic index (GI), glycemic load (GL), and adiponectin level contribute to glycemic response and insulin sensitivity in the body. Studies have shown that tumor development is related to glycemic disorders; however, the results are contradictory. We aimed to investigate the association of GI and GL with colorectal cancer (CRC) risk in a Korean population and their possible interactions with the genetic variant ADIPOQ T45G. Methods and results A case–control study including 2096 participants with 695 CRC cases was conducted. The results showed that diets with high GI or GL were significantly associated with an increased risk of CRC [odds ratio (OR) = 5.44, 95% confidence interval (CI) 3.85–7.68; OR = 4.43, 95% CI 3.18–6.15, respectively; all p -trends 
doi_str_mv 10.1007/s00394-022-02845-8
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Studies have shown that tumor development is related to glycemic disorders; however, the results are contradictory. We aimed to investigate the association of GI and GL with colorectal cancer (CRC) risk in a Korean population and their possible interactions with the genetic variant ADIPOQ T45G. Methods and results A case–control study including 2096 participants with 695 CRC cases was conducted. The results showed that diets with high GI or GL were significantly associated with an increased risk of CRC [odds ratio (OR) = 5.44, 95% confidence interval (CI) 3.85–7.68; OR = 4.43, 95% CI 3.18–6.15, respectively; all p -trends &lt; 0.001]. Moreover, even with a low-GI and low-GL diet, G/G genotype carriers may have 2.93-fold and 3.77-fold higher risk of rectal cancer compared to carriers of other genotypes (T/T + T/G), (OR = 2.93, 95% CI 1.01–8.59, p -interaction = 0.011 for GI; OR = 3.77, 95% CI 1.46–9.77, p -interaction = 0.025 for GL). Conclusions Overall, our study suggests positive associations of GI and GL with CRC risk. Moreover, the associations of GI and GL with rectal cancer risk could be modified by ADIPOQ T45G in a Korean population. Further studies with larger sample sizes are needed to confirm our findings.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-022-02845-8</identifier><identifier>PMID: 35243553</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adiponectin ; Adiponectin - genetics ; Blood Glucose ; Cancer ; Case-Control Studies ; Chemistry ; Chemistry and Materials Science ; Colorectal cancer ; Colorectal carcinoma ; Diet ; Dietary Carbohydrates ; Genetic diversity ; Genotype &amp; phenotype ; Genotypes ; Glycemic Index ; Glycemic Load ; Health risks ; Humans ; Insulin ; Mutation ; Nutrient deficiency ; Nutrition ; Original Contribution ; Population studies ; Rectal Neoplasms ; Rectum ; Republic of Korea - epidemiology ; Risk Factors ; Tumors</subject><ispartof>European journal of nutrition, 2022-08, Vol.61 (5), p.2601-2614</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-5d227e097ca1d1c1e2945a05a00fa0b517eb9e6e2a716f1e8ffbb8a1c114c2623</citedby><cites>FETCH-LOGICAL-c375t-5d227e097ca1d1c1e2945a05a00fa0b517eb9e6e2a716f1e8ffbb8a1c114c2623</cites><orcidid>0000-0002-0889-2686</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35243553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lu, Y-Thanh</creatorcontrib><creatorcontrib>Gunathilake, Madhawa</creatorcontrib><creatorcontrib>Lee, Jeonghee</creatorcontrib><creatorcontrib>Oh, Jae Hwan</creatorcontrib><creatorcontrib>Chang, Hee Jin</creatorcontrib><creatorcontrib>Sohn, Dae Kyung</creatorcontrib><creatorcontrib>Shin, Aesun</creatorcontrib><creatorcontrib>Kim, Jeongseon</creatorcontrib><title>The interaction between glycemic index, glycemic load, and the genetic variant ADIPOQ T45G (rs2241766) in the risk of colorectal cancer: a case–control study in a Korean population</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose The glycemic index (GI), glycemic load (GL), and adiponectin level contribute to glycemic response and insulin sensitivity in the body. Studies have shown that tumor development is related to glycemic disorders; however, the results are contradictory. We aimed to investigate the association of GI and GL with colorectal cancer (CRC) risk in a Korean population and their possible interactions with the genetic variant ADIPOQ T45G. Methods and results A case–control study including 2096 participants with 695 CRC cases was conducted. The results showed that diets with high GI or GL were significantly associated with an increased risk of CRC [odds ratio (OR) = 5.44, 95% confidence interval (CI) 3.85–7.68; OR = 4.43, 95% CI 3.18–6.15, respectively; all p -trends &lt; 0.001]. Moreover, even with a low-GI and low-GL diet, G/G genotype carriers may have 2.93-fold and 3.77-fold higher risk of rectal cancer compared to carriers of other genotypes (T/T + T/G), (OR = 2.93, 95% CI 1.01–8.59, p -interaction = 0.011 for GI; OR = 3.77, 95% CI 1.46–9.77, p -interaction = 0.025 for GL). Conclusions Overall, our study suggests positive associations of GI and GL with CRC risk. Moreover, the associations of GI and GL with rectal cancer risk could be modified by ADIPOQ T45G in a Korean population. Further studies with larger sample sizes are needed to confirm our findings.</description><subject>Adiponectin</subject><subject>Adiponectin - genetics</subject><subject>Blood Glucose</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>Diet</subject><subject>Dietary Carbohydrates</subject><subject>Genetic diversity</subject><subject>Genotype &amp; phenotype</subject><subject>Genotypes</subject><subject>Glycemic Index</subject><subject>Glycemic Load</subject><subject>Health risks</subject><subject>Humans</subject><subject>Insulin</subject><subject>Mutation</subject><subject>Nutrient deficiency</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Population studies</subject><subject>Rectal Neoplasms</subject><subject>Rectum</subject><subject>Republic of Korea - epidemiology</subject><subject>Risk Factors</subject><subject>Tumors</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhS0EoqXwAiyQJTZFasD_cdhVBUpFpYI0rKMb52ZIydiD7QCz4x14Fx6IJ8HTKa3EAsmWr-3vHF_5EPKYs-ecsfpFYkw2qmJClGmVruwdss-VNJURXN-9qVm9Rx6kdMkYE9Lw-2RPaqGk1nKf_Fp8Qjr6jBFcHoOnHeZviJ4up43D1ejKZY_fj273U4D-iILvaS7SJXrM5fQrxBF8psevzt5ffKALpU_pYUxCKF4b86y4XOFxTJ9pGKgLU4joMkzUgXcYX1IoVcLfP3664HMME0157jdbIdB3BQZP12E9T7Bt8yG5N8CU8NH1ekA-vnm9OHlbnV-cnp0cn1dO1jpXuheiRtbUDnjPHUfRKA2sDDYA6zSvsWvQoICam4GjHYaus1BIrpwwQh6Qw53vOoYvM6bcrsbkcJrAY5hTK0z5UGVts0Wf_oNehjn60l2hrK2NlUYVSuwoF0NKEYd2HccVxE3LWbtNtd2l2pZU26tUW1tET66t526F_Y3kb4wFkDsglSu_xHj79n9s_wDjf62h</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Lu, Y-Thanh</creator><creator>Gunathilake, Madhawa</creator><creator>Lee, Jeonghee</creator><creator>Oh, Jae Hwan</creator><creator>Chang, Hee Jin</creator><creator>Sohn, Dae Kyung</creator><creator>Shin, Aesun</creator><creator>Kim, Jeongseon</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0889-2686</orcidid></search><sort><creationdate>20220801</creationdate><title>The interaction between glycemic index, glycemic load, and the genetic variant ADIPOQ T45G (rs2241766) in the risk of colorectal cancer: a case–control study in a Korean population</title><author>Lu, Y-Thanh ; 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Studies have shown that tumor development is related to glycemic disorders; however, the results are contradictory. We aimed to investigate the association of GI and GL with colorectal cancer (CRC) risk in a Korean population and their possible interactions with the genetic variant ADIPOQ T45G. Methods and results A case–control study including 2096 participants with 695 CRC cases was conducted. The results showed that diets with high GI or GL were significantly associated with an increased risk of CRC [odds ratio (OR) = 5.44, 95% confidence interval (CI) 3.85–7.68; OR = 4.43, 95% CI 3.18–6.15, respectively; all p -trends &lt; 0.001]. Moreover, even with a low-GI and low-GL diet, G/G genotype carriers may have 2.93-fold and 3.77-fold higher risk of rectal cancer compared to carriers of other genotypes (T/T + T/G), (OR = 2.93, 95% CI 1.01–8.59, p -interaction = 0.011 for GI; OR = 3.77, 95% CI 1.46–9.77, p -interaction = 0.025 for GL). Conclusions Overall, our study suggests positive associations of GI and GL with CRC risk. Moreover, the associations of GI and GL with rectal cancer risk could be modified by ADIPOQ T45G in a Korean population. Further studies with larger sample sizes are needed to confirm our findings.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35243553</pmid><doi>10.1007/s00394-022-02845-8</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0002-0889-2686</orcidid></addata></record>
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subjects Adiponectin
Adiponectin - genetics
Blood Glucose
Cancer
Case-Control Studies
Chemistry
Chemistry and Materials Science
Colorectal cancer
Colorectal carcinoma
Diet
Dietary Carbohydrates
Genetic diversity
Genotype & phenotype
Genotypes
Glycemic Index
Glycemic Load
Health risks
Humans
Insulin
Mutation
Nutrient deficiency
Nutrition
Original Contribution
Population studies
Rectal Neoplasms
Rectum
Republic of Korea - epidemiology
Risk Factors
Tumors
title The interaction between glycemic index, glycemic load, and the genetic variant ADIPOQ T45G (rs2241766) in the risk of colorectal cancer: a case–control study in a Korean population
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