Evaluation of hydroxylated metabolites of polycyclic aromatic hydrocarbons and biomarkers of early kidney damage in indigenous children from Ticul, Yucatán, Mexico

• Published in: Environmental science and pollution research international 2021-10, Vol.28 (37), p.52001-52013
• Main Authors: Díaz de León-Martínez, Lorena, Ortega-Romero, Manolo S., Barbier, Olivier C., Pérez-Herrera, Norma, May-Euan, Fernando, Perera-Ríos, Javier, Rodríguez-Aguilar, Maribel, Flores-Ramírez, Rogelio
• Format: Article
• Language: English
• Subjects: 1-Hydroxypyrene; Aquatic Pollution; at-risk population; Atmospheric Protection/Air Quality Control/Air Pollution; Biomarkers; Biomedical materials; Biomonitoring; carcinogenicity; Carcinogens; Children; combustion; Creatinine; Cystatin C; Damage; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Health; environmental monitoring; Environmental science; Exposure; Gelatinase; Genotoxicity; humans; hydroxylation; Indigenous peoples; Kidneys; Leukocytes (neutrophilic); Lipocalin; Metabolites; Mexico; mutagens; neutrophils; Occupational exposure; Occupational health; Osteopontin; Pollutants; Polycyclic aromatic hydrocarbons; Population studies; Pottery; Research Article; smoke; Solid fuels; Teratogenicity; urine; Waste Water Technology; Water Management; Water Pollution Control
• ISSN: 0944-1344; 1614-7499
• DOI: 10.1007/s11356-021-14460-x

Polycyclic aromatic hydrocarbons (PAHs) are environmental persistent chemicals, produced by the incomplete combustion of solid fuels, found in smoke. PAHs are considered carcinogenic, teratogenic, and genotoxic. Children are susceptible to environmental pollutants, particularly those living in high-exposure settings. Therefore, the main objective of this study was to evaluate the exposure to PAHs through hydroxylated metabolites of PAHs (OH-PAHs), 1-hydroxynaphtalene (1-OH-NAP), and 2-hydroxynaphtalene (2-OH-NAP); 2-,3-, and 9-hydroxyfluorene (2-OH-FLU, 3-OH-FLU, 9-OH-FLU); 1-,2-,3-, and 4-hydroxyphenanthrene (1-OH-PHE, 2-OH-PHE, 3-OH-PHE, 4-OH-PHE); and 1-hydroxypyrene (1-OH-PYR), as well as kidney health through biomarkers of early kidney damage (osteopontin (OPN), neutrophil gelatinase-associated lipocalin (NGAL), α1-microglobulin (α1-MG), and cystatin C (Cys-C)) in children from an indigenous community dedicated to footwear manufacturing and pottery in Ticul, Yucatán, Mexico. The results show a high exposure to PAHs from the found concentrations of OH-PAHs in urine in 80.5% of the children in median concentrations of 18.4 (5.1-71.0) μg/L of total OH-PAHs, as well as concentrations of kidney damage proteins in 100% of the study population in concentrations of 4.8 (3-12.2) and 7.9 (6.5-13.7) μg/g creatinine of NGAL and Cys-C respectively, and 97.5% of the population with concentrations of OPN and α1-MG at mean concentrations of 207.3 (119.8-399.8) and 92.2 (68.5-165.5) μg/g creatinine. The information provided should be considered and addressed by the health authorities to establish continuous biomonitoring and programs to reduce para-occupational exposure in the vulnerable population, particularly children, based on their fundamental human right to health.