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A covalently cross-linked hyaluronic acid/bacterial cellulose composite hydrogel for potential biological applications

[Display omitted] •BC and HA were covalently crosslinked by BDDE.•Crosslinked BC/HA composites exhibited a denser and smoother surface.•BDDE crosslinking improved water retention capability, dimensional stability, and elongation at break of BC/HA composites .•Crosslinked BC/HA composites significant...

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Bibliographic Details
Published in:Carbohydrate polymers 2021-01, Vol.252, p.117123-117123, Article 117123
Main Authors: Tang, Shuo, Chi, Kai, Xu, Hui, Yong, Qiang, Yang, Jian, Catchmark, Jeffrey M.
Format: Article
Language:English
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Summary:[Display omitted] •BC and HA were covalently crosslinked by BDDE.•Crosslinked BC/HA composites exhibited a denser and smoother surface.•BDDE crosslinking improved water retention capability, dimensional stability, and elongation at break of BC/HA composites .•Crosslinked BC/HA composites significantly promoted cell proliferation. Bacterial cellulose (BC) is a good material candidate for wound dressing because of its fine 3-D network structure, high mechanical strength and water holding capability, and good biocompatibility. In this study, a composite hydrogel was prepared by using 1,4-butanediol diglycidyl ether (BDDE) to cross-link BC and hyaluronic acid (HA). Cross-linked BC/HA composites exhibited a denser and smoother surface. This dense morphology improved water retention capability and dimensional stability. BDDE cross-linked BC/HA composite with 2% HA and 1% BDDE showed better overall properties, including water stability (12.7 % water solubility), mechanical properties (tensile strength: ∼ 0.61 MPa and Young’s modulus: ∼1.62 MPa) and thermal stability (maximum degradation temperature: 360 °C), as compared to BC/HA without crosslinking. In addition, cell toxicity assays and morphology indicated the BDDE cross-linked BC/HA composite significantly promoted cell proliferation and adhesion. This chemically cross-linked BC/HA composite may have many new biomedical applications in wound care.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2020.117123