Protective Effect of Lacticaseibacillus casei CRL 431 Postbiotics on Mitochondrial Function and Oxidative Status in Rats with Aflatoxin B1–Induced Oxidative Stress

Studies have shown that the intracellular content of probiotic (postbiotics) has antioxidant properties, which can improve the antioxidant status in vivo. However, its absorption and mechanisms underlying the protective effects are still unknown. The antioxidant capacity of Lacticaseibacillus casei...

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Bibliographic Details
Published in:Probiotics and antimicrobial proteins 2021-08, Vol.13 (4), p.1033-1043
Main Authors: Guerrero-Encinas, Ildefonso, González-González, Javier Nicolás, Santiago-López, Lourdes, Muhlia-Almazán, Adriana, Garcia, Hugo Sergio, Mazorra-Manzano, Miguel Angel, Vallejo-Cordoba, Belinda, González-Córdova, Aarón F, Hernández-Mendoza, Adrián
Format: Article
Language:English
Subjects:
absorption
Aflatoxin B1
aflatoxins
Animal models
antioxidant activity
antioxidant enzymes
Antioxidants
Applied Microbiology
biomarkers
blood flow
Catalase
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Duodenum
Glutathione peroxidase
Hydrogen peroxide
Liver
Microbiology
Mitochondria
Nutrition
Oxidative stress
Permeability
Probiotics
protective effect
Protein Science
rats
Vitamin E
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Summary:Studies have shown that the intracellular content of probiotic (postbiotics) has antioxidant properties, which can improve the antioxidant status in vivo. However, its absorption and mechanisms underlying the protective effects are still unknown. The antioxidant capacity of Lacticaseibacillus casei CRL431 (IC-431) postbiotics was determined after an in vitro simulated digestive process. Permeability of antioxidant constituents of IC-431 was determined by an ex vivo everted duodenum assay. Aflatoxin B 1 –induced oxidative stress rat models were established and treated with IC-431; biomarkers of hepatic mitochondrial function and H 2 O 2 levels, oxidative stress, and oxidative stress index (OSi) were examined. The antioxidant capacity of IC-431 (477 ± 45.25 μmol Trolox Equivalent/L) was reduced by exposure to the simulated digestive process. No difference ( p  > 0.05) was found among digested and the permeate fraction of IC-431. A protective effect was observed by significantly lower OSi and higher liver glutathione peroxidase and catalase activities. Lower H 2 O 2 production, a higher degree of mitochondrial uncoupling, and lower mitochondrial respiration coefficient were also observed ( p  
ISSN:1867-1306
1867-1314
DOI:10.1007/s12602-021-09747-x