Associations between lung-deposited dose of particulate matter and culture-positive pulmonary tuberculosis pleurisy

• Published in: Environmental science and pollution research international 2022, Vol.29 (4), p.6140-6150
• Main Authors: Bai, Kuan-Jen, Tung, Nguyen Thanh, Hsiao, Ta-Chih, Chen, Tsai-Ling, Chung, Kian Fan, Ho, Shu-Chuan, Tsai, Cheng-Yu, Chen, Jen-Kun, Lee, Chun-Nin, Lee, Kang-Yun, Chang, Chih-Cheng, Chen, Tzu-Tao, Feng, Po-Hao, Chen, Kuan-Yuan, Su, Chien-Ling, Thao, Huynh Nguyen Xuan, Dung, Hoang Ba, Thuy, Tran Phan Chung, Lee, Yueh-Lun, Chuang, Hsiao-Chi
• Format: Article
• Language: English
• Subjects: Air Pollutants - analysis; Air pollution; Air Pollution - analysis; Air pollution measurements; Alveoli; Aquatic Pollution; Atmospheric Protection/Air Quality Control/Air Pollution; Biomarkers; Case-Control Studies; confidence interval; Confidence intervals; Congestive heart failure; Dosimeters; Dosimetry; drainage; Earth and Environmental Science; Ecotoxicology; Environment; Environmental Chemistry; Environmental Exposure - analysis; Environmental Health; Environmental science; Epidemiology; head; heart failure; Humans; Lung - chemistry; Lungs; Metals; Nitrogen Dioxide; nose; odds ratio; Particle deposition; Particulate emissions; Particulate matter; Particulate Matter - analysis; particulates; Pleural effusion; Pleurisy; regression analysis; Research Article; risk; Statistical analysis; Tuberculosis; Tuberculosis, Pulmonary; Waste Water Technology; Water Management; Water Pollution Control
• ISSN: 0944-1344; 1614-7499
• DOI: 10.1007/s11356-021-16008-5

Epidemiological studies identified the relationship between air pollution and pulmonary tuberculosis. Effects of lung-deposited dose of particulate matter (PM) on culture-positive pulmonary tuberculosis remain unclear. This study investigates the association between lung-deposited dose of PM and pulmonary tuberculosis pleurisy. A case-control study of subjects undergoing pleural effusion drainage of pulmonary tuberculosis (case) and chronic heart failure (control) was conducted. Metals and biomarkers were quantified in the pleural effusion. The air pollution exposure was measured and PM deposition in the head, tracheobronchial, alveolar region, and total lung region was estimated by Multiple-path Particle Dosimetry (MPPD) Model. We performed multiple logistic regression to examine the associations of these factors with the risk of tuberculosis. We observed that 1-μg/m 3 increase in PM 10 was associated with 1.226-fold increased crude odds ratio (OR) of tuberculosis (95% confidence interval (CI): 1.023–1.469, p