Anti‐phospholipid antibodies are elevated and functionally active in chronic rhinosinusitis with nasal polyps

Background Polyps from patients with chronic rhinosinusitis with nasal polyps (CRSwNP) contain increased levels of autoreactive antibodies, B cells and fibrin deposition. Anti‐phospholipid antibodies (APA) are autoantibodies known to cause thrombosis but have not been implicated in chronic rhinosinu...

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Bibliographic Details
Published in:Clinical and experimental allergy 2022-08, Vol.52 (8), p.954-964
Main Authors: Eide, Jacob G., Wu, Jeffanie, Stevens, Whitney W., Bai, Junqin, Hou, Songwang, Huang, Julia H., Rosenberg, Jacob, Utz, Paul, Shintani‐Smith, Stephanie, Conley, David B., Welch, Kevin C., Kern, Robert C., Hulse, Kathryn E., Peters, Anju T., Grammer, Leslie C., Zhao, Ming, Lindholm, Paul, Schleimer, Robert P., Tan, Bruce K.
Format: Article
Language:English
Subjects:
Antibodies
Antiphospholipid antibodies
anti‐phospholipid antibodies
Autoantibodies
Cardiolipin
Chronic Disease
Coagulation
Enzyme-linked immunosorbent assay
Fibrin
Humans
Immunoglobulin G
Lymphocytes B
nasal polyps
Nasal Polyps - complications
Phosphatidylethanolamine
Phospholipids
Polyps
Rhinitis
Rhinosinusitis
Sinusitis
Thrombin
Thromboplastin
Thrombosis
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Summary:Background Polyps from patients with chronic rhinosinusitis with nasal polyps (CRSwNP) contain increased levels of autoreactive antibodies, B cells and fibrin deposition. Anti‐phospholipid antibodies (APA) are autoantibodies known to cause thrombosis but have not been implicated in chronic rhinosinusitis (CRS). Objective To compare APA levels (anti‐cardiolipin, anti‐phosphatidylethanolamine (anti‐PE), and anti‐β2‐glycoprotein (anti‐B2GP)) in nasal polyp (NP) tissue with tissue from control and CRS without nasal polyp (CRSsNP) patients, we tested whether NP antibodies affect coagulation, and correlate APAs with anti‐dsDNA IgG and markers of coagulation. Methods Patient specimens were assayed for APA IgG, anti‐dsDNA IgG and thrombin‐anti‐thrombin (TaT) complex by ELISA. Antibodies from a subset of specimens were tested for modified activated partial thromboplastin time (aPTT) measured on an optical‐mechanical coagulometer. Results Anti‐cardiolipin IgG in NP was 5‐fold higher than control tissue (p 
ISSN:0954-7894
1365-2222
DOI:10.1111/cea.14120