Effects of brassinosteroids on cancer cells: A review

Brassinolide is a new type of steroidal hormone with strong activities, which is well known as an efficient and low‐toxicity plant growth regulator for a long time. Because steroidal hormones have a wide application prospect, brassinosteroids have been gradually explored in pharmacology and animal c...

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Published in:Journal of biochemical and molecular toxicology 2022-06, Vol.36 (6), p.e23026-n/a
Main Authors: Ma, Feifan, An, Zaiyong, Yue, Qiulin, Zhao, Chen, Zhang, Song, Sun, Xin, Li, Kunlun, Zhao, Lin, Su, Le
Format: Article
Language:English
Subjects:
Animals
Anticancer properties
Antitumor activity
Antitumor agents
Apoptosis
Brassinolide
Brassinosteroids
Brassinosteroids - pharmacology
Cancer
Cholestanols - metabolism
Cholestanols - pharmacology
Effusion
Glycoproteins
Growth regulators
Hormones
Neoplasms - drug therapy
Pharmacology
Plant growth
Plant Growth Regulators - pharmacology
Plant hormones
Toxicity
Wound healing
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Summary:Brassinolide is a new type of steroidal hormone with strong activities, which is well known as an efficient and low‐toxicity plant growth regulator for a long time. Because steroidal hormones have a wide application prospect, brassinosteroids have been gradually explored in pharmacology and animal cells in recent decades. Brassinolide could effectively reverse the resistance of human T lymphoblastoid cell line CCRF‐VCR 1000 by inhibiting the effusion of drug transported by P‐glycoprotein. Brassinosteroids could also accelerate wound healing by positively eliminating inflammation and stimulating reepithelialization of the reparation stage. The occurrence of cancer is a multistep process mediated by a variety of factors. Until now, cancer has always been one group of the major diseases that threaten human health. Many studies have found that brassinosteroids have attracted a great deal of potential as an anticancer agent in the treatment of cancer cells, and most of them exert anticancer activity by inducing apoptosis in cancer cells. There are few articles on the relationship between brassinosteroids and cancer so far. Accordingly, in this article, we summarized current research about the brassinosteroids and cancers. Through the review, researchers could know more about brassinosteroids which might become a new tool for the treatment of cancer in the future, and not only a plant hormone.
ISSN:1095-6670
1099-0461
DOI:10.1002/jbt.23026