Caspase mechanisms in the regulation of inflammation

Regulated cell death is defined as genetically encoded pathways that lead towards the demise of cells. In mammals, cell demise can be either inflammatory or non-inflammatory, depending on whether the mechanism of death results in cell rupture or not. Inflammatory cell death can lead towards acute an...

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Bibliographic Details
Published in:Molecular aspects of medicine 2022-12, Vol.88, p.101085-101085, Article 101085
Main Authors: Bibo-Verdugo, Betsaida, Salvesen, Guy S.
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Apoptosis - genetics
Apoptosome
Caspase
Caspases - genetics
Caspases - metabolism
Cell death
Humans
Inflammasome
Inflammasomes - metabolism
Inflammation
Inflammation necroptosis
Mammals
Necroptosis
Protease
Pyroptosis
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Summary:Regulated cell death is defined as genetically encoded pathways that lead towards the demise of cells. In mammals, cell demise can be either inflammatory or non-inflammatory, depending on whether the mechanism of death results in cell rupture or not. Inflammatory cell death can lead towards acute and chronic disease. Therefore, it becomes important to distinguish the mechanisms that result in these different inflammatory cell death outcomes. Apoptosis is a non-inflammatory form of cell death where cells resist rupture. In contrast, pyroptosis and necroptosis are inflammatory forms of cell death principally because of release of pro-inflammatory mediators from cells undergoing lysis. This review focusses on the mechanisms of these different cell death outcomes with specific emphasis on the caspase family of proteolytic enzymes.
ISSN:0098-2997
1872-9452
DOI:10.1016/j.mam.2022.101085