A comparative study on regulation of HLA-G expression in bad obstetric history and in head and neck squamous cell carcinoma from Northeast India

• Published in: Human immunology 2022-05, Vol.83 (5), p.453-457
• Main Authors: Bora, Mayuri, Sarmah, Neelanjana, Das, Bhaswatee, Narayan Baruah, Munindra, Deka, Gitanjali, Gogoi Hazarika, Sumita, Baruah, Shashi
• Format: Article
• Language: English
• Subjects: 14base pair Insertion/Deletion; 3' Untranslated Regions; 3142C>G SNP; Abortion, Spontaneous - genetics; Case-Control Studies; Female; Head and Neck Neoplasms; HLA-G; HLA-G Antigens - genetics; HNSCC; Humans; India; MicroRNAs - genetics; miR-148A; miR-152; Placenta; Pregnancy; SAB; Squamous Cell Carcinoma of Head and Neck
• ISSN: 0198-8859; 1879-1166
• DOI: 10.1016/j.humimm.2022.02.006

The expression of immunomodulatory molecule HLA-G is tissue restricted with abundant expression in placenta, mediating immune tolerance to fetus. Tumors hijack HLA-G to establish nutrient supply and evade host immune response. 14 base pair Insertion/Deletion polymorphism (rs371194629) and + 3142 G/C SNP (rs1063320) of 3′UTR of HLA-G were investigated in conjunction with miR-148A, miR-152 and HLA-G expression in SAB (Spontaneous abortion) history placenta and HNSCC tumor in a hospital-based case control study. Higher frequency of G allele of rs1063320 was seen in study participants as reported in other global populations. Both miR-148A and miR-152 were downregulated in tumor tissue. Predominance of 14 base pair “IN” allele of rs371194629 was noted in SAB placental tissue (p =