Loading…
Maternal stress induced autophagy dysfunction and immune activation in the hippocampus of adolescence rat pups
Maternal stress (MS) has long-term effects on fetal brain development and consequently increases the risk of neuropsychiatric diseases in the offspring, however, the mechanism that links between early life stress and subsequent neuropsychiatric diseases is still not clear. It is well known that both...
Saved in:
Published in: | Journal of chemical neuroanatomy 2022-04, Vol.121, p.102085-102085, Article 102085 |
---|---|
Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c368t-1132bada080c4a0fd1054bd44c24ab146ea89f963a6a3d8fa9fa8b4ad48b70b93 |
---|---|
cites | cdi_FETCH-LOGICAL-c368t-1132bada080c4a0fd1054bd44c24ab146ea89f963a6a3d8fa9fa8b4ad48b70b93 |
container_end_page | 102085 |
container_issue | |
container_start_page | 102085 |
container_title | Journal of chemical neuroanatomy |
container_volume | 121 |
creator | Surakul, Pornprom Chutabhakdikul, Nuanchan Vanichviriyakit, Rapeepun Promthep, Kornkanok Thangnipon, Wipawan |
description | Maternal stress (MS) has long-term effects on fetal brain development and consequently increases the risk of neuropsychiatric diseases in the offspring, however, the mechanism that links between early life stress and subsequent neuropsychiatric diseases is still not clear. It is well known that both neuroinflammation and autophagy dysfunction contributes to the pathology of psychiatric disorders. We hypothesized that MS might alter autophagy function and activate the neuroimmune response in the pup’s brain. To test this hypothesis, we investigated the effects of MS on the expression of the autophagy biomarker and neuroimmune response in the hippocampus of rat pups. Results revealed that MS-induced a long-term decrease of LC3B-II throughout the postnatal periods, together with an increase of IL-6 and IL-10 in the hippocampus of rat pups during adolescence. These changes lasted at least until adulthood. Results from the In vitro studies showed that a partially toxic dose of corticosterone (CORT) induced a significant decrease of LC3B-II, together with an increase of IL-6 and IL-10, in the SH-SY5Y cells. Moreover, suppression of autophagy by mycophenolic acid (MPA) leads to an increased IL-6 and IL-10 expression in the CORT-treated SH-SY5Y cells. Findings suggested that CORT decreased autophagy dysfunction could activate neuroimmune response in the SH-SY5Y cells. Results from this study provides initial evidence for the relationship between stress hormone, autophagy dysfunction, and neuroimmune activation, which may be the linking mechanism between early-life stress and subsequent neuropsychiatric disorders.
•Maternal stress decreased autophagy function in the hippocampus of neonatal rat pups at least until adulthood.•Maternal stress activates the neuroimmune response in the hippocampus of rat pups from adolescence to adulthood.•Suppression of autophagy activate immune response in the CORT-treated SH-SY5Y cells.•Autophagy dysfunction may be the linking mechanism between early-life stress and subsequent neuropsychiatric disorders. |
doi_str_mv | 10.1016/j.jchemneu.2022.102085 |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2637337711</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0891061822000151</els_id><sourcerecordid>2637337711</sourcerecordid><originalsourceid>FETCH-LOGICAL-c368t-1132bada080c4a0fd1054bd44c24ab146ea89f963a6a3d8fa9fa8b4ad48b70b93</originalsourceid><addsrcrecordid>eNqFkEuP1DAQhC0EYoeBv7DykUsGO3Yc5wZa8ZIWcYGz1bE7jEeJHfxYaf49GWaXK6eWSlVd3R8ht5wdOOPq3elwskdcAtZDy9p2E1umu2dkx3UvGiUYe052TA-8YYrrG_Iq5xNjvBNSvSQ3omu7Xvf9joRvUDAFmGkuCXOmPrhq0VGoJa5H-HWm7pynGmzxMVAIjvplqQEpbMoD_FV9oOWI9OjXNVpY1pppnCi4OGO2GCzSBIWudc2vyYsJ5oxvHuee_Pz08cfdl-b---evdx_uGyuULg3noh3BAdPMSmCT46yTo5PSthJGLhWCHqZBCVAgnJ5gmECPEpzUY8_GQezJ2-veNcXfFXMxi99OmWcIGGs2rRK9EH2_Fe2JulptijknnMya_ALpbDgzF9bmZJ5Ymwtrc2W9BW8fO-q4oPsXe4K7Gd5fDbh9-uAxmWz9BYfzCW0xLvr_dfwBWl6WNw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2637337711</pqid></control><display><type>article</type><title>Maternal stress induced autophagy dysfunction and immune activation in the hippocampus of adolescence rat pups</title><source>Elsevier</source><creator>Surakul, Pornprom ; Chutabhakdikul, Nuanchan ; Vanichviriyakit, Rapeepun ; Promthep, Kornkanok ; Thangnipon, Wipawan</creator><creatorcontrib>Surakul, Pornprom ; Chutabhakdikul, Nuanchan ; Vanichviriyakit, Rapeepun ; Promthep, Kornkanok ; Thangnipon, Wipawan</creatorcontrib><description>Maternal stress (MS) has long-term effects on fetal brain development and consequently increases the risk of neuropsychiatric diseases in the offspring, however, the mechanism that links between early life stress and subsequent neuropsychiatric diseases is still not clear. It is well known that both neuroinflammation and autophagy dysfunction contributes to the pathology of psychiatric disorders. We hypothesized that MS might alter autophagy function and activate the neuroimmune response in the pup’s brain. To test this hypothesis, we investigated the effects of MS on the expression of the autophagy biomarker and neuroimmune response in the hippocampus of rat pups. Results revealed that MS-induced a long-term decrease of LC3B-II throughout the postnatal periods, together with an increase of IL-6 and IL-10 in the hippocampus of rat pups during adolescence. These changes lasted at least until adulthood. Results from the In vitro studies showed that a partially toxic dose of corticosterone (CORT) induced a significant decrease of LC3B-II, together with an increase of IL-6 and IL-10, in the SH-SY5Y cells. Moreover, suppression of autophagy by mycophenolic acid (MPA) leads to an increased IL-6 and IL-10 expression in the CORT-treated SH-SY5Y cells. Findings suggested that CORT decreased autophagy dysfunction could activate neuroimmune response in the SH-SY5Y cells. Results from this study provides initial evidence for the relationship between stress hormone, autophagy dysfunction, and neuroimmune activation, which may be the linking mechanism between early-life stress and subsequent neuropsychiatric disorders.
•Maternal stress decreased autophagy function in the hippocampus of neonatal rat pups at least until adulthood.•Maternal stress activates the neuroimmune response in the hippocampus of rat pups from adolescence to adulthood.•Suppression of autophagy activate immune response in the CORT-treated SH-SY5Y cells.•Autophagy dysfunction may be the linking mechanism between early-life stress and subsequent neuropsychiatric disorders.</description><identifier>ISSN: 0891-0618</identifier><identifier>EISSN: 1873-6300</identifier><identifier>DOI: 10.1016/j.jchemneu.2022.102085</identifier><identifier>PMID: 35257877</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescence ; Adult ; Animals ; Autophagy ; Corticosterone ; Hippocampus ; Hippocampus - metabolism ; Humans ; Interleukin-10 - metabolism ; Interleukin-6 - metabolism ; Maternal stress ; Neuroimmune activation ; Rats</subject><ispartof>Journal of chemical neuroanatomy, 2022-04, Vol.121, p.102085-102085, Article 102085</ispartof><rights>2022 Elsevier B.V.</rights><rights>Copyright © 2022 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c368t-1132bada080c4a0fd1054bd44c24ab146ea89f963a6a3d8fa9fa8b4ad48b70b93</citedby><cites>FETCH-LOGICAL-c368t-1132bada080c4a0fd1054bd44c24ab146ea89f963a6a3d8fa9fa8b4ad48b70b93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35257877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Surakul, Pornprom</creatorcontrib><creatorcontrib>Chutabhakdikul, Nuanchan</creatorcontrib><creatorcontrib>Vanichviriyakit, Rapeepun</creatorcontrib><creatorcontrib>Promthep, Kornkanok</creatorcontrib><creatorcontrib>Thangnipon, Wipawan</creatorcontrib><title>Maternal stress induced autophagy dysfunction and immune activation in the hippocampus of adolescence rat pups</title><title>Journal of chemical neuroanatomy</title><addtitle>J Chem Neuroanat</addtitle><description>Maternal stress (MS) has long-term effects on fetal brain development and consequently increases the risk of neuropsychiatric diseases in the offspring, however, the mechanism that links between early life stress and subsequent neuropsychiatric diseases is still not clear. It is well known that both neuroinflammation and autophagy dysfunction contributes to the pathology of psychiatric disorders. We hypothesized that MS might alter autophagy function and activate the neuroimmune response in the pup’s brain. To test this hypothesis, we investigated the effects of MS on the expression of the autophagy biomarker and neuroimmune response in the hippocampus of rat pups. Results revealed that MS-induced a long-term decrease of LC3B-II throughout the postnatal periods, together with an increase of IL-6 and IL-10 in the hippocampus of rat pups during adolescence. These changes lasted at least until adulthood. Results from the In vitro studies showed that a partially toxic dose of corticosterone (CORT) induced a significant decrease of LC3B-II, together with an increase of IL-6 and IL-10, in the SH-SY5Y cells. Moreover, suppression of autophagy by mycophenolic acid (MPA) leads to an increased IL-6 and IL-10 expression in the CORT-treated SH-SY5Y cells. Findings suggested that CORT decreased autophagy dysfunction could activate neuroimmune response in the SH-SY5Y cells. Results from this study provides initial evidence for the relationship between stress hormone, autophagy dysfunction, and neuroimmune activation, which may be the linking mechanism between early-life stress and subsequent neuropsychiatric disorders.
•Maternal stress decreased autophagy function in the hippocampus of neonatal rat pups at least until adulthood.•Maternal stress activates the neuroimmune response in the hippocampus of rat pups from adolescence to adulthood.•Suppression of autophagy activate immune response in the CORT-treated SH-SY5Y cells.•Autophagy dysfunction may be the linking mechanism between early-life stress and subsequent neuropsychiatric disorders.</description><subject>Adolescence</subject><subject>Adult</subject><subject>Animals</subject><subject>Autophagy</subject><subject>Corticosterone</subject><subject>Hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Humans</subject><subject>Interleukin-10 - metabolism</subject><subject>Interleukin-6 - metabolism</subject><subject>Maternal stress</subject><subject>Neuroimmune activation</subject><subject>Rats</subject><issn>0891-0618</issn><issn>1873-6300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqFkEuP1DAQhC0EYoeBv7DykUsGO3Yc5wZa8ZIWcYGz1bE7jEeJHfxYaf49GWaXK6eWSlVd3R8ht5wdOOPq3elwskdcAtZDy9p2E1umu2dkx3UvGiUYe052TA-8YYrrG_Iq5xNjvBNSvSQ3omu7Xvf9joRvUDAFmGkuCXOmPrhq0VGoJa5H-HWm7pynGmzxMVAIjvplqQEpbMoD_FV9oOWI9OjXNVpY1pppnCi4OGO2GCzSBIWudc2vyYsJ5oxvHuee_Pz08cfdl-b---evdx_uGyuULg3noh3BAdPMSmCT46yTo5PSthJGLhWCHqZBCVAgnJ5gmECPEpzUY8_GQezJ2-veNcXfFXMxi99OmWcIGGs2rRK9EH2_Fe2JulptijknnMya_ALpbDgzF9bmZJ5Ymwtrc2W9BW8fO-q4oPsXe4K7Gd5fDbh9-uAxmWz9BYfzCW0xLvr_dfwBWl6WNw</recordid><startdate>202204</startdate><enddate>202204</enddate><creator>Surakul, Pornprom</creator><creator>Chutabhakdikul, Nuanchan</creator><creator>Vanichviriyakit, Rapeepun</creator><creator>Promthep, Kornkanok</creator><creator>Thangnipon, Wipawan</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202204</creationdate><title>Maternal stress induced autophagy dysfunction and immune activation in the hippocampus of adolescence rat pups</title><author>Surakul, Pornprom ; Chutabhakdikul, Nuanchan ; Vanichviriyakit, Rapeepun ; Promthep, Kornkanok ; Thangnipon, Wipawan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-1132bada080c4a0fd1054bd44c24ab146ea89f963a6a3d8fa9fa8b4ad48b70b93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescence</topic><topic>Adult</topic><topic>Animals</topic><topic>Autophagy</topic><topic>Corticosterone</topic><topic>Hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Humans</topic><topic>Interleukin-10 - metabolism</topic><topic>Interleukin-6 - metabolism</topic><topic>Maternal stress</topic><topic>Neuroimmune activation</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Surakul, Pornprom</creatorcontrib><creatorcontrib>Chutabhakdikul, Nuanchan</creatorcontrib><creatorcontrib>Vanichviriyakit, Rapeepun</creatorcontrib><creatorcontrib>Promthep, Kornkanok</creatorcontrib><creatorcontrib>Thangnipon, Wipawan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of chemical neuroanatomy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Surakul, Pornprom</au><au>Chutabhakdikul, Nuanchan</au><au>Vanichviriyakit, Rapeepun</au><au>Promthep, Kornkanok</au><au>Thangnipon, Wipawan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal stress induced autophagy dysfunction and immune activation in the hippocampus of adolescence rat pups</atitle><jtitle>Journal of chemical neuroanatomy</jtitle><addtitle>J Chem Neuroanat</addtitle><date>2022-04</date><risdate>2022</risdate><volume>121</volume><spage>102085</spage><epage>102085</epage><pages>102085-102085</pages><artnum>102085</artnum><issn>0891-0618</issn><eissn>1873-6300</eissn><abstract>Maternal stress (MS) has long-term effects on fetal brain development and consequently increases the risk of neuropsychiatric diseases in the offspring, however, the mechanism that links between early life stress and subsequent neuropsychiatric diseases is still not clear. It is well known that both neuroinflammation and autophagy dysfunction contributes to the pathology of psychiatric disorders. We hypothesized that MS might alter autophagy function and activate the neuroimmune response in the pup’s brain. To test this hypothesis, we investigated the effects of MS on the expression of the autophagy biomarker and neuroimmune response in the hippocampus of rat pups. Results revealed that MS-induced a long-term decrease of LC3B-II throughout the postnatal periods, together with an increase of IL-6 and IL-10 in the hippocampus of rat pups during adolescence. These changes lasted at least until adulthood. Results from the In vitro studies showed that a partially toxic dose of corticosterone (CORT) induced a significant decrease of LC3B-II, together with an increase of IL-6 and IL-10, in the SH-SY5Y cells. Moreover, suppression of autophagy by mycophenolic acid (MPA) leads to an increased IL-6 and IL-10 expression in the CORT-treated SH-SY5Y cells. Findings suggested that CORT decreased autophagy dysfunction could activate neuroimmune response in the SH-SY5Y cells. Results from this study provides initial evidence for the relationship between stress hormone, autophagy dysfunction, and neuroimmune activation, which may be the linking mechanism between early-life stress and subsequent neuropsychiatric disorders.
•Maternal stress decreased autophagy function in the hippocampus of neonatal rat pups at least until adulthood.•Maternal stress activates the neuroimmune response in the hippocampus of rat pups from adolescence to adulthood.•Suppression of autophagy activate immune response in the CORT-treated SH-SY5Y cells.•Autophagy dysfunction may be the linking mechanism between early-life stress and subsequent neuropsychiatric disorders.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>35257877</pmid><doi>10.1016/j.jchemneu.2022.102085</doi><tpages>1</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0891-0618 |
ispartof | Journal of chemical neuroanatomy, 2022-04, Vol.121, p.102085-102085, Article 102085 |
issn | 0891-0618 1873-6300 |
language | eng |
recordid | cdi_proquest_miscellaneous_2637337711 |
source | Elsevier |
subjects | Adolescence Adult Animals Autophagy Corticosterone Hippocampus Hippocampus - metabolism Humans Interleukin-10 - metabolism Interleukin-6 - metabolism Maternal stress Neuroimmune activation Rats |
title | Maternal stress induced autophagy dysfunction and immune activation in the hippocampus of adolescence rat pups |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T13%3A47%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Maternal%20stress%20induced%20autophagy%20dysfunction%20and%20immune%20activation%20in%20the%20hippocampus%20of%20adolescence%20rat%20pups&rft.jtitle=Journal%20of%20chemical%20neuroanatomy&rft.au=Surakul,%20Pornprom&rft.date=2022-04&rft.volume=121&rft.spage=102085&rft.epage=102085&rft.pages=102085-102085&rft.artnum=102085&rft.issn=0891-0618&rft.eissn=1873-6300&rft_id=info:doi/10.1016/j.jchemneu.2022.102085&rft_dat=%3Cproquest_cross%3E2637337711%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c368t-1132bada080c4a0fd1054bd44c24ab146ea89f963a6a3d8fa9fa8b4ad48b70b93%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2637337711&rft_id=info:pmid/35257877&rfr_iscdi=true |