Phytochemical-loaded liposomes for anticancer therapy: an updated review

The major obstacles observed in current chemotherapy are severe adverse effects, narrow therapeutic indexes and multidrug resistance. Anticancer phytochemicals are extracted and purified from natural plants, providing alternative therapeutic approaches with recognized biomedical benefits. However, p...

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Bibliographic Details
Published in:Nanomedicine (London, England) England), 2022-04, Vol.17 (8), p.547-568
Main Authors: Chavda, Vivek P, Vihol, Disha, Mehta, Bhavya, Shah, Dhruvil, Patel, Manan, Vora, Lalitkumar K, Pereira-Silva, Miguel, Paiva-Santos, Ana Cláudia
Format: Article
Language:English
Subjects:
anticancer
Antineoplastic Agents - therapeutic use
Drug Delivery Systems
Drug Resistance, Multiple
Humans
liposome
Liposomes - chemistry
marketed product
nanoformulation
Neoplasms - drug therapy
phytochemical
Phytochemicals - therapeutic use
Phytotherapy
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Summary:The major obstacles observed in current chemotherapy are severe adverse effects, narrow therapeutic indexes and multidrug resistance. Anticancer phytochemicals are extracted and purified from natural plants, providing alternative therapeutic approaches with recognized biomedical benefits. However, poor bioavailability, high dose requirements and non-specific targeting have made those molecules less effective. To tackle those issues, liposomal nanovesicles for phytochemical delivery are taken into consideration for improving the therapeutic effectiveness by increasing transportation across cell barriers and conferring attractive cancer-specific targeting capabilities. In the present review, the liposomal approaches of anticancer phytochemicals are discussed, and recent advances in these formulations applied to cancer phytotherapy are further reviewed by an informed approach. This review describes the application of liposomal phyto-chemotherapy as a promising therapeutic and technological intervention against cancer that has the potential to enhance the effectiveness of cancer therapy, reduce the associated side effects and improve the clinical outcomes of cancer patients.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2021-0463