Focused ultrasound and other lesioning in the treatment of tremor

There has been a long history of lesioning procedures to treat tremor associated with both essential tremor (ET) and Parkinson's disease (PD). These include radiofrequency (RF) thalamotomy, gamma knife radiosurgical (GKRS) thalamotomy, and magnetic resonance-guided focused ultrasound (MRgFUS)....

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Bibliographic Details
Published in:Journal of the neurological sciences 2022-04, Vol.435, p.120193-120193, Article 120193
Main Authors: Binder, Devin K., Shah, Binit B., Elias, W. Jeffrey
Format: Article
Language:English
Subjects:
Deep brain stimulation
Essential tremor
Essential Tremor - diagnostic imaging
Essential Tremor - surgery
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Parkinson Disease - surgery
Parkinson Disease - therapy
Parkinson's disease
Radiosurgery
Thalamus - diagnostic imaging
Thalamus - surgery
Thermometry
Treatment Outcome
Tremor - diagnostic imaging
Tremor - therapy
Ultrasound
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Summary:There has been a long history of lesioning procedures to treat tremor associated with both essential tremor (ET) and Parkinson's disease (PD). These include radiofrequency (RF) thalamotomy, gamma knife radiosurgical (GKRS) thalamotomy, and magnetic resonance-guided focused ultrasound (MRgFUS). In this review, we summarize the clinical studies of lesioning procedures for tremor focusing on these ablative therapies for ET and tremor-predominant PD (TDPD). We then consider clinical treatment variables that influence decision-making regarding ablative therapies versus consideration of deep brain stimulation (DBS) and conclude with ongoing and future studies. This article is part of the Special Issue "Tremor" edited by Daniel D. Truong, Mark Hallett, and Aasef Shaikh. •This manuscript reviews the methods and outcome of lesioning procedures for the treatment of tremor.•Focused ultrasound, gamma knife, and radiofrequency procedures are compared.•Choice of lesioning versus deep brain stimulation is discussed.
ISSN:0022-510X
1878-5883
DOI:10.1016/j.jns.2022.120193