A Multifunctional Janus Electrospun Nanofiber Dressing with Biofluid Draining, Monitoring, and Antibacterial Properties for Wound Healing

Wound healing greatly affects patients’ health and produces medical burden. Therefore, we developed a multifunctional electrospun nanofiber dressing, which can inhibit methicillin-resistant Staphylococcus aureus (MRSA), drain excessive biofluid to promote wound healing, and simultaneously monitor wo...

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Bibliographic Details
Published in:ACS applied materials & interfaces 2022-03, Vol.14 (11), p.12984-13000
Main Authors: Zhang, Xinming, Lv, Ruijuan, Chen, Lixia, Sun, Ruimeng, Zhang, Yang, Sheng, Rongtian, Du, Ting, Li, Yuhan, Qi, Yanfei
Format: Article
Language:English
Subjects:
Anions
Anti-Bacterial Agents - pharmacology
Bandages
Biological and Medical Applications of Materials and Interfaces
Humans
Methicillin-Resistant Staphylococcus aureus
Nanofibers - chemistry
Polyelectrolytes
Wound Healing
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Summary:Wound healing greatly affects patients’ health and produces medical burden. Therefore, we developed a multifunctional electrospun nanofiber dressing, which can inhibit methicillin-resistant Staphylococcus aureus (MRSA), drain excessive biofluid to promote wound healing, and simultaneously monitor wound pH level. The polyoxometalate (α-K6P2W18O62·14H2O, P2W18) and oxacillin (OXA) are encapsulated in hydrophobic polylactide (PLA) nanofiber to synergistically inhibit MRSA. The phenol red (PSP) is encapsulated in hydrophilic polyacrylonitrile (PAN) nanofiber to sensitively indicate wound pH in situ. The PSP/PAN nanofiber is directly electrospun on the patterning OXA/P2W18/PLA nanofiber layer to form a Janus dressing. By taking advantage of the wettability difference between the two layers, the excess biofluid can be drained away from the wound. In addition, the Janus dressing exhibits good biocompatibility and accelerates wound healing via its antimicrobial activity and skin repairing function. This multifunctional Janus electrospun nanofiber dressing would be beneficial for wound management and treatment.
ISSN:1944-8244
1944-8252
DOI:10.1021/acsami.1c22629