Effect of omega‐3 fatty acids on premenstrual syndrome: A systematic review and meta‐analysis

• Published in: The journal of obstetrics and gynaecology research 2022-06, Vol.48 (6), p.1293-1305
• Main Authors: Mohammadi, Mohammad Mehdi, Dehghan Nayeri, Nahid, Mashhadi, Monireh, Varaei, Shokoh
• Format: Article
• Language: English
• Subjects: Aging; Clinical trials; Fatty acids; Fatty Acids, Omega-3 - pharmacology; Fatty Acids, Omega-3 - therapeutic use; Female; Humans; Menstrual cycle; Meta-analysis; Omega-3 fatty acids; omega‐3; PMS; Polyunsaturated fatty acids; Premenstrual syndrome; Premenstrual Syndrome - drug therapy; Reviews; Systematic review
• ISSN: 1341-8076; 1447-0756
• DOI: 10.1111/jog.15217

Introduction To date, no definitive results have been reported on the effect of omega‐3 fatty acids on premenstrual syndrome (PMS). Therefore, this systematic review and meta‐analysis aimed to determine the effect of omega‐3 fatty acids on PMS. Methods In this systematic review and meta‐analysis, the databases were searched. In this regard, randomized clinical trials investigating the effect of omega‐3 fatty acids on PMS were included. The quality of the studies was assessed using the Cochrane Collaboration's Risk of Bias tool. Meta‐analysis was done based on random effects model and calculation of standardized mean difference (SMDs). Results The results of meta‐analysis showed that omega‐3 fatty acids were efficient in reducing the severity of PMS in women (SMD = −0.968, 95% confidence interval [CI]: −1.471 to −0.464). In addition, the results showed that the studies were heterogeneous (I2 = 89.11%, p