Predictors of hyperkinetic seizures

•Hyperkinetic seizure diagnosis may be a challenge even for expert clinicians.•Sleep and type II FCD act independently in favoring hyperkinetic seizures.•Hyperkinetic seizures and complex motor automatisms in preschool children are uncommon. To identify predisposing factors for hyperkinetic seizure...

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Published in:Epilepsy & behavior 2022-04, Vol.129, p.108629-108629, Article 108629
Main Authors: Menghi, Veronica, Bisulli, Francesca, Cardinale, Francesco, Vignatelli, Luca, Zenesini, Corrado, Mai, Roberto, Proserpio, Paola, Francione, Stefano, Sartori, Ivana, Tinuper, Paolo, Nobili, Lino
Format: Article
Language:English
Subjects:
Disorders of arousal
Drug-resistance
Electroencephalography
Epilepsy surgery
Epilepsy, Reflex - complications
Follow-Up Studies
Humans
Hyperkinetic seizures
Magnetic Resonance Imaging
Male
Retrospective Studies
Seizures - complications
Seizures - diagnosis
Seizures - surgery
Treatment Outcome
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Summary:•Hyperkinetic seizure diagnosis may be a challenge even for expert clinicians.•Sleep and type II FCD act independently in favoring hyperkinetic seizures.•Hyperkinetic seizures and complex motor automatisms in preschool children are uncommon. To identify predisposing factors for hyperkinetic seizure occurrence in a representative cohort of surgically treated patients with drug-resistant focal epilepsy. We retrospectively recruited all seizure-free patients after epilepsy surgery with a postoperative follow-up ≥12 months. Patients were classified as presenting with hyperkinetic seizures if at least 2 episodes occurred during their disease history, based on clear-cut anamnestic description and/or video-EEG/stereo-EEG recordings. We performed univariable and multivariable logistic regression models to study the association between the occurrence of hyperkinetic seizures and some predictors. From a pool of 1758 consecutive patients who underwent surgery from 1996 to 2017, we identified 974 seizure-free cases. Considering at least 1-year follow-up, 937 cases were included (511 males, 91 patients with hyperkinetic seizures). Variables significantly associated with an increased risk of hyperkinetic seizure occurrence were (1) presence of epilepsy with sleep-related seizures (SRE) (P 
ISSN:1525-5050
1525-5069
DOI:10.1016/j.yebeh.2022.108629