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The impact of anti-endothelial cell antibodies (AECAs) on the development of blood vessel damage in patients with systemic lupus erythematosus: the preliminary study
Vascular injury represents one of the most frequent lesions in systemic lupus erythematosus (SLE). The aim of the study was to assess the influence of anti-endothelial cell antibodies (AECAs) on the development of endothelial cell (EC) activation, dysfunction and subsequent vasculitis in women with...
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Published in: | Rheumatology international 2022-05, Vol.42 (5), p.791-801 |
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description | Vascular injury represents one of the most frequent lesions in systemic lupus erythematosus (SLE). The aim of the study was to assess the influence of anti-endothelial cell antibodies (AECAs) on the development of endothelial cell (EC) activation, dysfunction and subsequent vasculitis in women with SLE. Fifty six women with SLE were divided into 2 subgroups, i.e. subjects with positive AECAs (+) and those with negative AECAs (–). The control group consisted of 25 healthy women. Clinical characteristics, routine laboratory tests and circulating markers of EC activation/dysfunction, i.e. monocyte-chemotactic protein-1 (MCP-1), soluble E- and P-selectin, vascular and intercellular adhesion molecule-1 (sVCAM-1, sICAM-1), von Willebrand factor (vWF), pentraxin 3 (the marker of vasculitis) the indicator of procoagulant activity i.e. prothrombin fragment 1 + 2 (F1 + 2) were detected using ELISA and compared between patients with AECA (+), AECA (–) and control subgroups. Serum concentrations of AECAs in AECA(+), AECA(–) and control groups were 4.58 ± 2.97, 0.92 ± 0.50 and 0.72 ± 0.28 AU/ml, respectively (
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doi_str_mv | 10.1007/s00296-022-05104-5 |
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p <
0.001). The study showed significant increases in EC activation markers, i.e. MCP-1, sE-selectin, sVCAM-1 and F1 + 2 in SLE AECA(+) compared to SLE AECA(–) and control groups. However, the indicator of vasculitis (PTX3) was significantly lower in SLE AECA(+). Moreover, multivariate analysis of variance showed a positive correlation between AECAs and sE-selectin and sVCAM-1 levels, but not with PTX3. AECAs were involved in the initial stages of vascular damage in SLE, i.e. in EC activation and dysfunction. However, they did not play a role in the development of vasculitis.</description><identifier>ISSN: 1437-160X</identifier><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-022-05104-5</identifier><identifier>PMID: 35284968</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Antibodies ; Autoantibodies ; Biomarkers ; Blood vessels ; Cardiovascular disease ; Creatinine ; Endothelium, Vascular ; Female ; Humans ; Laboratories ; Lupus ; Lupus Erythematosus, Systemic ; Medicine ; Medicine & Public Health ; Observational Research ; Plasma ; Proteins ; Rheumatology ; Vasculitis - pathology ; Womens health</subject><ispartof>Rheumatology international, 2022-05, Vol.42 (5), p.791-801</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-a68eb5ae4d9cc84000124904bbfd7486b5822372775fbf9547e830ee71c6f0703</citedby><cites>FETCH-LOGICAL-c375t-a68eb5ae4d9cc84000124904bbfd7486b5822372775fbf9547e830ee71c6f0703</cites><orcidid>0000-0002-3723-3591 ; 0000-0002-3289-1050 ; 0000-0002-7871-528X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35284968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cieślik, Paweł</creatorcontrib><creatorcontrib>Semik-Grabarczyk, Elżbieta</creatorcontrib><creatorcontrib>Hrycek, Antoni</creatorcontrib><creatorcontrib>Holecki, Michał</creatorcontrib><title>The impact of anti-endothelial cell antibodies (AECAs) on the development of blood vessel damage in patients with systemic lupus erythematosus: the preliminary study</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><addtitle>Rheumatol Int</addtitle><description>Vascular injury represents one of the most frequent lesions in systemic lupus erythematosus (SLE). The aim of the study was to assess the influence of anti-endothelial cell antibodies (AECAs) on the development of endothelial cell (EC) activation, dysfunction and subsequent vasculitis in women with SLE. Fifty six women with SLE were divided into 2 subgroups, i.e. subjects with positive AECAs (+) and those with negative AECAs (–). The control group consisted of 25 healthy women. Clinical characteristics, routine laboratory tests and circulating markers of EC activation/dysfunction, i.e. monocyte-chemotactic protein-1 (MCP-1), soluble E- and P-selectin, vascular and intercellular adhesion molecule-1 (sVCAM-1, sICAM-1), von Willebrand factor (vWF), pentraxin 3 (the marker of vasculitis) the indicator of procoagulant activity i.e. prothrombin fragment 1 + 2 (F1 + 2) were detected using ELISA and compared between patients with AECA (+), AECA (–) and control subgroups. Serum concentrations of AECAs in AECA(+), AECA(–) and control groups were 4.58 ± 2.97, 0.92 ± 0.50 and 0.72 ± 0.28 AU/ml, respectively (
p <
0.001). The study showed significant increases in EC activation markers, i.e. MCP-1, sE-selectin, sVCAM-1 and F1 + 2 in SLE AECA(+) compared to SLE AECA(–) and control groups. However, the indicator of vasculitis (PTX3) was significantly lower in SLE AECA(+). Moreover, multivariate analysis of variance showed a positive correlation between AECAs and sE-selectin and sVCAM-1 levels, but not with PTX3. AECAs were involved in the initial stages of vascular damage in SLE, i.e. in EC activation and dysfunction. However, they did not play a role in the development of vasculitis.</description><subject>Antibodies</subject><subject>Autoantibodies</subject><subject>Biomarkers</subject><subject>Blood vessels</subject><subject>Cardiovascular disease</subject><subject>Creatinine</subject><subject>Endothelium, Vascular</subject><subject>Female</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Lupus</subject><subject>Lupus Erythematosus, Systemic</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Observational Research</subject><subject>Plasma</subject><subject>Proteins</subject><subject>Rheumatology</subject><subject>Vasculitis - pathology</subject><subject>Womens health</subject><issn>1437-160X</issn><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhS0EomXgBVggS2zKIuXGseOE3WhUaKVKbIrELnLim44rJw65Tqt5IN4Td6aFqgtWtuzvnPtzGHufw2kOoD8TgKjLDITIQOUgM_WCHeey0Flews-XT-5H7A3RDUCuyxJes6NCiUrWZXXMfl9tkbthMl3koedmjC7D0Ya4Re-M5x16v39tg3VI_GR9tlnTJx5GnhBu8RZ9mAYc9_LWh2D5LRKh59YM5jqZj3wy0SWC-J2LW047iji4jvtlWojjvEtOg4mBFvqyd53mVHxwo5l3nOJid2_Zq954wncP54r9-Hp2tTnPLr9_u9isL7Ou0CpmpqywVQalrbuukpAGFrIG2ba91bIqW1UJUWihterbvlZSY1UAos67sgcNxYqdHHynOfxakGIzOLpfgRkxLNSIsqhqCWmJCf34DL0Jyzym7hIl60oqmegVEweqmwPRjH0zzW5IczU5NPchNocQmxRisw-xUUn04cF6aQe0fyWPqSWgOACUvsZrnP_V_o_tH-fdqaQ</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>Cieślik, Paweł</creator><creator>Semik-Grabarczyk, Elżbieta</creator><creator>Hrycek, Antoni</creator><creator>Holecki, Michał</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3723-3591</orcidid><orcidid>https://orcid.org/0000-0002-3289-1050</orcidid><orcidid>https://orcid.org/0000-0002-7871-528X</orcidid></search><sort><creationdate>20220501</creationdate><title>The impact of anti-endothelial cell antibodies (AECAs) on the development of blood vessel damage in patients with systemic lupus erythematosus: the preliminary study</title><author>Cieślik, Paweł ; Semik-Grabarczyk, Elżbieta ; Hrycek, Antoni ; Holecki, Michał</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-a68eb5ae4d9cc84000124904bbfd7486b5822372775fbf9547e830ee71c6f0703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antibodies</topic><topic>Autoantibodies</topic><topic>Biomarkers</topic><topic>Blood vessels</topic><topic>Cardiovascular disease</topic><topic>Creatinine</topic><topic>Endothelium, Vascular</topic><topic>Female</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Lupus</topic><topic>Lupus Erythematosus, Systemic</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Observational Research</topic><topic>Plasma</topic><topic>Proteins</topic><topic>Rheumatology</topic><topic>Vasculitis - pathology</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cieślik, Paweł</creatorcontrib><creatorcontrib>Semik-Grabarczyk, Elżbieta</creatorcontrib><creatorcontrib>Hrycek, Antoni</creatorcontrib><creatorcontrib>Holecki, Michał</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cieślik, Paweł</au><au>Semik-Grabarczyk, Elżbieta</au><au>Hrycek, Antoni</au><au>Holecki, Michał</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of anti-endothelial cell antibodies (AECAs) on the development of blood vessel damage in patients with systemic lupus erythematosus: the preliminary study</atitle><jtitle>Rheumatology international</jtitle><stitle>Rheumatol Int</stitle><addtitle>Rheumatol Int</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>42</volume><issue>5</issue><spage>791</spage><epage>801</epage><pages>791-801</pages><issn>1437-160X</issn><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>Vascular injury represents one of the most frequent lesions in systemic lupus erythematosus (SLE). The aim of the study was to assess the influence of anti-endothelial cell antibodies (AECAs) on the development of endothelial cell (EC) activation, dysfunction and subsequent vasculitis in women with SLE. Fifty six women with SLE were divided into 2 subgroups, i.e. subjects with positive AECAs (+) and those with negative AECAs (–). The control group consisted of 25 healthy women. Clinical characteristics, routine laboratory tests and circulating markers of EC activation/dysfunction, i.e. monocyte-chemotactic protein-1 (MCP-1), soluble E- and P-selectin, vascular and intercellular adhesion molecule-1 (sVCAM-1, sICAM-1), von Willebrand factor (vWF), pentraxin 3 (the marker of vasculitis) the indicator of procoagulant activity i.e. prothrombin fragment 1 + 2 (F1 + 2) were detected using ELISA and compared between patients with AECA (+), AECA (–) and control subgroups. Serum concentrations of AECAs in AECA(+), AECA(–) and control groups were 4.58 ± 2.97, 0.92 ± 0.50 and 0.72 ± 0.28 AU/ml, respectively (
p <
0.001). The study showed significant increases in EC activation markers, i.e. MCP-1, sE-selectin, sVCAM-1 and F1 + 2 in SLE AECA(+) compared to SLE AECA(–) and control groups. However, the indicator of vasculitis (PTX3) was significantly lower in SLE AECA(+). Moreover, multivariate analysis of variance showed a positive correlation between AECAs and sE-selectin and sVCAM-1 levels, but not with PTX3. AECAs were involved in the initial stages of vascular damage in SLE, i.e. in EC activation and dysfunction. However, they did not play a role in the development of vasculitis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35284968</pmid><doi>10.1007/s00296-022-05104-5</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-3723-3591</orcidid><orcidid>https://orcid.org/0000-0002-3289-1050</orcidid><orcidid>https://orcid.org/0000-0002-7871-528X</orcidid></addata></record> |
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subjects | Antibodies Autoantibodies Biomarkers Blood vessels Cardiovascular disease Creatinine Endothelium, Vascular Female Humans Laboratories Lupus Lupus Erythematosus, Systemic Medicine Medicine & Public Health Observational Research Plasma Proteins Rheumatology Vasculitis - pathology Womens health |
title | The impact of anti-endothelial cell antibodies (AECAs) on the development of blood vessel damage in patients with systemic lupus erythematosus: the preliminary study |
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