Organotropic Targeting of Biomimetic Nanoparticles to Treat Lung Disease

Active targeting strategies aimed at improving drug homing while reducing systemic toxicity are widely being pursued in the growing field of nanomedicine. While they can be effective, these approaches often require the identification of cell-specific targets and in-depth knowledge of receptor bindin...

Full description

Saved in:
Bibliographic Details
Published in:Bioconjugate chemistry 2022-04, Vol.33 (4), p.586-593
Main Authors: Holay, Maya, Zhou, Jiarong, Park, Joon Ho, Landa, Igor, Ventura, Christian J, Gao, Weiwei, Fang, Ronnie H, Zhang, Liangfang
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Bioaccumulation
Biocompatibility
Biomimetic Materials - chemistry
Biomimetic Materials - therapeutic use
Biomimetics
Breast cancer
Cell membranes
Cytokines
Dexamethasone
Drug Delivery Systems
Exosomes
Humans
Inflammation
Lung cancer
Lung Diseases
Metastases
Nanoengineering
Nanomedicine
Nanoparticles
Nanoparticles - chemistry
Nanotechnology
Payloads
Surface markers
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Active targeting strategies aimed at improving drug homing while reducing systemic toxicity are widely being pursued in the growing field of nanomedicine. While they can be effective, these approaches often require the identification of cell-specific targets and in-depth knowledge of receptor binding interactions. More recently, there has been significant interest in biomimetic nanoformulations capable of replicating the properties of naturally occurring systems. In particular, the advent of cell membrane coating nanotechnology has enabled researchers to leverage the inherent tropisms displayed by living cells, bypassing many of the challenges associated with traditional bottom-up nanoengineering. In this work, we report on a biomimetic organotropic nanodelivery system for localizing therapeutic payloads to the lungs. Metastatic breast cancer exosomes, which are lung tropic due to their unique surface marker expression profile, are used to coat nanoparticle cores loaded with the anti-inflammatory drug dexamethasone. In vivo, these nanoparticles demonstrate enhanced accumulation in lung tissue and significantly reduce proinflammatory cytokine burden in a lung inflammation model. Overall, this work highlights the potential of using biomimetic organ-level delivery strategies for the management of certain disease conditions.
ISSN:1043-1802
1520-4812
DOI:10.1021/acs.bioconjchem.1c00599