Tumour generated exosomal miRNAs: A major player in tumour angiogenesis

One of the major reasons for the non-effectiveness of anticancer therapeutics designed to target tumour angiogenesis is the involvement of multiple layers of cellular communication that exists within the tumour microenvironment. Any attempt to block one signaling pathway by targeting one of its comp...

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Bibliographic Details
Published in:Biochimica et biophysica acta. Molecular basis of disease 2022-06, Vol.1868 (6), p.166383-166383, Article 166383
Main Authors: Kumar, V.B. Sameer, Anjali, K.
Format: Article
Language:English
Subjects:
Angiogenesis
Exosomes
Exosomes - metabolism
Humans
MicroRNAs - genetics
MicroRNAs - metabolism
miRNAs
Neoplasms - pathology
Neovascularization, Pathologic - pathology
Tumor Microenvironment - genetics
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Summary:One of the major reasons for the non-effectiveness of anticancer therapeutics designed to target tumour angiogenesis is the involvement of multiple layers of cellular communication that exists within the tumour microenvironment. Any attempt to block one signaling pathway by targeting one of its components led to the activation of alternate pathway that overcome this block rendering the therapy ineffective. During the previous decades most of the research was focused on manipulating signaling pathways initiated by soluble factors and their intermediates. More recently the work from our lab and many advanced labs all over the globe have brought into light, the significance of signaling events mediated by exosomes in regulation of tumour progression and angiogenesis. In this mini review we intend to collate the information available from several groups including ours related to the role of exosomal cargo especially exosomal miRNAs in modulating tumour angiogenesis.
ISSN:0925-4439
1879-260X
DOI:10.1016/j.bbadis.2022.166383