Enhanced phase-amplitude coupling of human electrocorticography selectively in the posterior cortical region during rapid eye movement sleep

The spatiotemporal dynamics of interaction between slow (delta or infraslow) waves and fast (gamma) activities during wakefulness and sleep are yet to be elucidated in human electrocorticography (ECoG). We evaluated phase-amplitude coupling (PAC), which reflects neuronal coding in information proces...

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Published in:Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2022-12, Vol.33 (2), p.486-496
Main Authors: Togawa, Jumpei, Matsumoto, Riki, Usami, Kiyohide, Matsuhashi, Masao, Inouchi, Morito, Kobayashi, Katsuya, Hitomi, Takefumi, Nakae, Takuro, Shimotake, Akihiro, Yamao, Yukihiro, Kikuchi, Takayuki, Yoshida, Kazumichi, Kunieda, Takeharu, Miyamoto, Susumu, Takahashi, Ryosuke, Ikeda, Akio
Format: Article
Language:English
Subjects:
Electrocorticography
Electroencephalography
Humans
Sleep - physiology
Sleep, REM - physiology
Sleep, Slow-Wave - physiology
Wakefulness - physiology
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Summary:The spatiotemporal dynamics of interaction between slow (delta or infraslow) waves and fast (gamma) activities during wakefulness and sleep are yet to be elucidated in human electrocorticography (ECoG). We evaluated phase-amplitude coupling (PAC), which reflects neuronal coding in information processing, using ECoG in 11 patients with intractable focal epilepsy. PAC was observed between slow waves of 0.5-0.6 Hz and gamma activities, not only during light sleep and slow-wave sleep (SWS) but even during wakefulness and rapid eye movement (REM) sleep. While PAC was high over a large region during SWS, it was stronger in the posterior cortical region around the temporoparietal junction than in the frontal cortical region during REM sleep. PAC tended to be higher in the posterior cortical region than in the frontal cortical region even during wakefulness. Our findings suggest that the posterior cortical region has a functional role in REM sleep and may contribute to the maintenance of the dreaming experience.
ISSN:1047-3211
1460-2199
DOI:10.1093/cercor/bhac079