The isolation, structural features and biological activities of polysaccharide from Ligusticum chuanxiong: A review

• Published in: Carbohydrate polymers 2022-06, Vol.285, p.118971-118971, Article 118971
• Main Authors: Wang, Jie, Wang, Lei, Zhou, Hui, Liang, Xiao-dong, Zhang, Meng-tian, Tang, Ying-xue, Wang, Ji-hui, Mao, Jin-long
• Format: Article
• Language: English
• Subjects: Adjuvants, Immunologic - pharmacology; Adjuvants, Immunologic - therapeutic use; Animals; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Antioxidants - pharmacology; Antioxidants - therapeutic use; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Biological activity; Carbohydrate Conformation; Carbohydrate Sequence; COVID-19; COVID-19 - drug therapy; COVID-19 - virology; Drugs, Chinese Herbal; Humans; Ligusticum - chemistry; Ligusticum chuanxiong; Pectic polysaccharide; Polysaccharides - chemistry; Polysaccharides - isolation & purification; Polysaccharides - pharmacology; SARS-CoV-2 - drug effects; SARS-CoV-2 - isolation & purification; Structural feature
• ISSN: 0144-8617; 1879-1344
• DOI: 10.1016/j.carbpol.2021.118971

Ligusticum chuanxiong, the dried rhizome of Ligusticum chuanxiong Hort, has been widely applied in traditional Chinese medicine for treating plague, and it has appeared frequently in the prescriptions against COVID-19 lately. Ligusticum chuanxiong polysaccharide (LCPs) is one of the effective substances, which has various activities, such as, anti-oxidation, promoting immunity, anti-tumor, and anti-bacteria. The purified fractions of LCPs are considered to be pectic polysaccharides, which are mainly composed of GalA, Gal, Ara and Rha, and are generally linked by α-1,4-d-GalpA, α-1,2-l-Rhap, α-1,5-l-Araf, β-1,3-d-Galp and β-1,4-d-Galp, etc. The pectic polysaccharide shows an anti-infective inflammatory activity, which is related to antiviral infection of Ligusticum chuanxiong. In this article, the isolation, purification, structural features, and biological activities of LCPs in recent years are reviewed, and the potential of LCPs against viral infection as well as questions that need future research are discussed. [Display omitted]