Impact of Nutritional Profile on Gut Microbiota Diversity in Patients with Celiac Disease

The pathogenesis of celiac disease (CD) is significantly influenced by gut microbiota. Daily nutritional profile influences the diversity of gut microbiota. This study was aimed to compare the abundance of gut microbiota in CD patients compared to normal control (NC), and to investigate the impact o...

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Bibliographic Details
Published in:Current microbiology 2022-05, Vol.79 (5), p.129-129, Article 129
Main Authors: Soheilian-Khorzoghi, Mona, Rezasoltani, Sama, Moheb-Alian, Ali, Yadegar, Abbas, Rostami-Nejad, Mohammad, Azizmohammad-Looha, Mehdi, Verma, Anil Kumar, Haddadi, Azam, Dabiri, Hossein
Format: Article
Language:English
Subjects:
Abundance
Autoimmune diseases
Bacteria
Beans
Bifidobacterium
Bifidobacterium - genetics
Biomedical and Life Sciences
Biotechnology
Celiac Disease
Confectionery
Correlation coefficient
Correlation coefficients
Digestive system
Fecal microflora
Feces
Feces - microbiology
Firmicutes
Gastrointestinal Microbiome
Gastrointestinal tract
Gluten
Humans
Intestinal microflora
Lactobacillus
Life Sciences
Meat
Microbiology
Microbiota
Pathogenesis
Probiotics
Signs and symptoms
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Summary:The pathogenesis of celiac disease (CD) is significantly influenced by gut microbiota. Daily nutritional profile influences the diversity of gut microbiota. This study was aimed to compare the abundance of gut microbiota in CD patients compared to normal control (NC), and to investigate the impact of nutritional factors on their fecal microbiota diversity. In this study, a selected panel of intestinal bacteria was assessed in 31 confirmed CD patients adhering to gluten-free diet (GFD) for more than 6 months and in 20 NC subjects. Stool samples were collected from each participant, DNA was extracted, and absolute quantitative real-time PCR (qPCR) was carried out. The gut microbiota including Bacteroidetes , Bifidobacterium , Clostridium , Staphylococcus , Enterobacteiaceae , Firmicutes , and Lactobacillus were assessed. The quantities of fruits, vegetables, meat, liquids, sugar and gluten-free candy/bread consumption were evaluated using a questionnaire. The proportion of Bifidobacterium , Firmicutes, and Lactobacillus in CD cases was significantly lower than NC ( P  
ISSN:0343-8651
1432-0991
DOI:10.1007/s00284-022-02820-w