Adipocyte‐specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction

Adipose tissue regulates whole‐body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin‐dependent kinases (CDKs) have been reported to be involved in adipos...

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Bibliographic Details
Published in:FEBS letters 2022-06, Vol.596 (11), p.1434-1444
Main Authors: Chen, Yizhe, Fernandez, Eric Aria, Roger, Catherine, Lopez‐Mejia, Isabel C., Fajas Coll, Lluis, Ji, Honglei
Format: Article
Language:English
Subjects:
adipose tissue
cyclin‐dependent kinase 7
lipid metabolism
lipodystrophy
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Summary:Adipose tissue regulates whole‐body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin‐dependent kinases (CDKs) have been reported to be involved in adipose tissue development and functions. Using adipose tissue‐specific knockout mice, here we demonstrate that the deletion of CDK7 in adipose tissue results in progressive lipodystrophy, insulin resistance, impaired adipokine secretion and downregulation of fat‐specific genes, which are aggravated on high‐fat diet and during ageing. Our studies suggest that CDK7 is a key regulatory component of adipose tissue maintenance and systemic energy homeostasis. Adipocyte‐specific cyclin‐dependent kinase 7 (CDK7) knockout mice exhibit impaired lipid metabolism‐related gene expression, shrinking adipocyte size, fat loss, hepatomegaly and insulin resistance upon high‐fat diet (HFD) feeding and during ageing, which point to a lipodystrophic phenotype, suggesting Cdk7 is a vital regulator of adipose tissue maintenance and systemic energy homeostasis.
ISSN:0014-5793
1873-3468
DOI:10.1002/1873-3468.14335