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Adipocyte‐specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction
Adipose tissue regulates whole‐body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin‐dependent kinases (CDKs) have been reported to be involved in adipos...
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Published in: | FEBS letters 2022-06, Vol.596 (11), p.1434-1444 |
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creator | Chen, Yizhe Fernandez, Eric Aria Roger, Catherine Lopez‐Mejia, Isabel C. Fajas Coll, Lluis Ji, Honglei |
description | Adipose tissue regulates whole‐body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin‐dependent kinases (CDKs) have been reported to be involved in adipose tissue development and functions. Using adipose tissue‐specific knockout mice, here we demonstrate that the deletion of CDK7 in adipose tissue results in progressive lipodystrophy, insulin resistance, impaired adipokine secretion and downregulation of fat‐specific genes, which are aggravated on high‐fat diet and during ageing. Our studies suggest that CDK7 is a key regulatory component of adipose tissue maintenance and systemic energy homeostasis.
Adipocyte‐specific cyclin‐dependent kinase 7 (CDK7) knockout mice exhibit impaired lipid metabolism‐related gene expression, shrinking adipocyte size, fat loss, hepatomegaly and insulin resistance upon high‐fat diet (HFD) feeding and during ageing, which point to a lipodystrophic phenotype, suggesting Cdk7 is a vital regulator of adipose tissue maintenance and systemic energy homeostasis. |
doi_str_mv | 10.1002/1873-3468.14335 |
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Adipocyte‐specific cyclin‐dependent kinase 7 (CDK7) knockout mice exhibit impaired lipid metabolism‐related gene expression, shrinking adipocyte size, fat loss, hepatomegaly and insulin resistance upon high‐fat diet (HFD) feeding and during ageing, which point to a lipodystrophic phenotype, suggesting Cdk7 is a vital regulator of adipose tissue maintenance and systemic energy homeostasis.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1002/1873-3468.14335</identifier><identifier>PMID: 35294049</identifier><language>eng</language><publisher>England</publisher><subject>adipose tissue ; cyclin‐dependent kinase 7 ; lipid metabolism ; lipodystrophy</subject><ispartof>FEBS letters, 2022-06, Vol.596 (11), p.1434-1444</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies</rights><rights>2022 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3395-1f837ef7c363e061bd0c3136ca427d3ae48ade09ef8f6dcf81a4f58d54b784e13</cites><orcidid>0000-0002-3762-3637 ; 0000-0002-1283-9503 ; 0000-0003-1790-8296</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35294049$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Yizhe</creatorcontrib><creatorcontrib>Fernandez, Eric Aria</creatorcontrib><creatorcontrib>Roger, Catherine</creatorcontrib><creatorcontrib>Lopez‐Mejia, Isabel C.</creatorcontrib><creatorcontrib>Fajas Coll, Lluis</creatorcontrib><creatorcontrib>Ji, Honglei</creatorcontrib><title>Adipocyte‐specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Adipose tissue regulates whole‐body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin‐dependent kinases (CDKs) have been reported to be involved in adipose tissue development and functions. Using adipose tissue‐specific knockout mice, here we demonstrate that the deletion of CDK7 in adipose tissue results in progressive lipodystrophy, insulin resistance, impaired adipokine secretion and downregulation of fat‐specific genes, which are aggravated on high‐fat diet and during ageing. Our studies suggest that CDK7 is a key regulatory component of adipose tissue maintenance and systemic energy homeostasis.
Adipocyte‐specific cyclin‐dependent kinase 7 (CDK7) knockout mice exhibit impaired lipid metabolism‐related gene expression, shrinking adipocyte size, fat loss, hepatomegaly and insulin resistance upon high‐fat diet (HFD) feeding and during ageing, which point to a lipodystrophic phenotype, suggesting Cdk7 is a vital regulator of adipose tissue maintenance and systemic energy homeostasis.</description><subject>adipose tissue</subject><subject>cyclin‐dependent kinase 7</subject><subject>lipid metabolism</subject><subject>lipodystrophy</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNqFkDFOwzAUQC0EoqUwsyGPLGnt2EmcsZQWEJVYYLYc-xuMkqbECSgbR-CMnISElK5Mlq33n_wfQueUTCkh4YyKhAWMx2JKOWPRARrvXw7RmBDKgyhJ2QideP9Kurug6TEasShMOeHpGL3MjduWuq3h-_PLb0E76zReXN8nWGW5ql25wTko43Fd4m1VPlfgvXsHnJfe49Ji1c97wLXzvgGsNgYXUKuszDuPab1tNrq3nKIjq3IPZ7tzgp5Wy8fFbbB-uLlbzNeBZiyNAmoFS8AmmsUMSEwzQzSjLNaKh4lhCrhQBkgKVtjYaCuo4jYSJuJZIjhQNkGXg7f77FsDvpaF8xryXG2gbLwMY04I5zHjHTobUF11y1Rg5bZyhapaSYns88o-puxjyt-83cTFTt5kBZg9_9ezA-IB-HA5tP_55Gp5FQ7mH-xDhuc</recordid><startdate>202206</startdate><enddate>202206</enddate><creator>Chen, Yizhe</creator><creator>Fernandez, Eric Aria</creator><creator>Roger, Catherine</creator><creator>Lopez‐Mejia, Isabel C.</creator><creator>Fajas Coll, Lluis</creator><creator>Ji, Honglei</creator><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3762-3637</orcidid><orcidid>https://orcid.org/0000-0002-1283-9503</orcidid><orcidid>https://orcid.org/0000-0003-1790-8296</orcidid></search><sort><creationdate>202206</creationdate><title>Adipocyte‐specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction</title><author>Chen, Yizhe ; Fernandez, Eric Aria ; Roger, Catherine ; Lopez‐Mejia, Isabel C. ; Fajas Coll, Lluis ; Ji, Honglei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3395-1f837ef7c363e061bd0c3136ca427d3ae48ade09ef8f6dcf81a4f58d54b784e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>adipose tissue</topic><topic>cyclin‐dependent kinase 7</topic><topic>lipid metabolism</topic><topic>lipodystrophy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Yizhe</creatorcontrib><creatorcontrib>Fernandez, Eric Aria</creatorcontrib><creatorcontrib>Roger, Catherine</creatorcontrib><creatorcontrib>Lopez‐Mejia, Isabel C.</creatorcontrib><creatorcontrib>Fajas Coll, Lluis</creatorcontrib><creatorcontrib>Ji, Honglei</creatorcontrib><collection>Open Access: Wiley-Blackwell Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Yizhe</au><au>Fernandez, Eric Aria</au><au>Roger, Catherine</au><au>Lopez‐Mejia, Isabel C.</au><au>Fajas Coll, Lluis</au><au>Ji, Honglei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adipocyte‐specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2022-06</date><risdate>2022</risdate><volume>596</volume><issue>11</issue><spage>1434</spage><epage>1444</epage><pages>1434-1444</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Adipose tissue regulates whole‐body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin‐dependent kinases (CDKs) have been reported to be involved in adipose tissue development and functions. Using adipose tissue‐specific knockout mice, here we demonstrate that the deletion of CDK7 in adipose tissue results in progressive lipodystrophy, insulin resistance, impaired adipokine secretion and downregulation of fat‐specific genes, which are aggravated on high‐fat diet and during ageing. Our studies suggest that CDK7 is a key regulatory component of adipose tissue maintenance and systemic energy homeostasis.
Adipocyte‐specific cyclin‐dependent kinase 7 (CDK7) knockout mice exhibit impaired lipid metabolism‐related gene expression, shrinking adipocyte size, fat loss, hepatomegaly and insulin resistance upon high‐fat diet (HFD) feeding and during ageing, which point to a lipodystrophic phenotype, suggesting Cdk7 is a vital regulator of adipose tissue maintenance and systemic energy homeostasis.</abstract><cop>England</cop><pmid>35294049</pmid><doi>10.1002/1873-3468.14335</doi><tpages>1444</tpages><orcidid>https://orcid.org/0000-0002-3762-3637</orcidid><orcidid>https://orcid.org/0000-0002-1283-9503</orcidid><orcidid>https://orcid.org/0000-0003-1790-8296</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | adipose tissue cyclin‐dependent kinase 7 lipid metabolism lipodystrophy |
title | Adipocyte‐specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction |
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