Aberrant protein networks in Alzheimer disease

Use of a proteomics approach has demonstrated that changes in protein expression association with Alzheimer disease are not always reflected in changes in RNA levels, highlighting the importance of directly studying proteomic changes to a full understanding of Alzheimer disease pathogenesis.

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Bibliographic Details
Published in:Nature reviews. Neurology 2022-05, Vol.18 (5), p.255-256
Main Authors: Perluigi, Marzia, Barone, Eugenio
Format: Article
Language:English
Subjects:
631/378/1689/1283
692/617/375/132/1283
Alzheimer Disease - metabolism
Alzheimer's disease
Asymptomatic
Brain - metabolism
Brain research
Dementia
Down syndrome
Gene expression
Health risk assessment
Humans
Kinases
Medicine
Medicine & Public Health
Metabolism
Neurology
News & Views
news-and-views
Pathogenesis
Protein expression
Proteins
Proteomics
Scientific imaging
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Description
Summary:Use of a proteomics approach has demonstrated that changes in protein expression association with Alzheimer disease are not always reflected in changes in RNA levels, highlighting the importance of directly studying proteomic changes to a full understanding of Alzheimer disease pathogenesis.
ISSN:1759-4758
1759-4766
DOI:10.1038/s41582-022-00648-3