Angiogenic factors for planning fetal surveillance in fetal growth restriction and small‐for‐gestational‐age fetuses: A prospective observational study

Objective The aim of this study was to assess the added value of the soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) ratio for adjusting the periodicity of ultrasound examinations in early‐onset fetal growth restriction (FGR) and small for gestational age (SGA). Design...

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Bibliographic Details
Published in:BJOG : an international journal of obstetrics and gynaecology 2022-10, Vol.129 (11), p.1870-1877
Main Authors: Bonacina, Erika, Mendoza, Manel, Farràs, Alba, Garcia‐Manau, Pablo, Serrano, Berta, Hurtado, Ivan, Ferrer‐Oliveras, Raquel, Illan, Lidia, Armengol‐Alsina, Mireia, Carreras, Elena
Format: Article
Language:English
Subjects:
Angiogenesis
Angiogenesis Inducing Agents
Biomarkers
Diagnosis
Female
fetal Doppler
fetal growth restriction
Fetal Growth Retardation - diagnostic imaging
fetal surveillance
Fetuses
Humans
Observational studies
Periodicity
Placenta Growth Factor
PlGF
Pre-Eclampsia - diagnosis
Predictive Value of Tests
Pregnancy
Prospective Studies
Protein-tyrosine kinase
sFlt‐1
Small-for-gestational age
Surveillance
Ultrasonic imaging
Ultrasound
Umbilical Arteries - diagnostic imaging
Vascular Endothelial Growth Factor Receptor-1
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Summary:Objective The aim of this study was to assess the added value of the soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) ratio for adjusting the periodicity of ultrasound examinations in early‐onset fetal growth restriction (FGR) and small for gestational age (SGA). Design A prospective, observational study. Setting Tertiary referral hospital. Population One hundred and thirty‐four single pregnancies with ultrasonographic estimated fetal weight (EFW) below the 10th centile between 20+0 and 31+6 weeks of gestation with antegrade umbilical artery flow. Methods The time from Doppler and sFlt‐1/PlGF assessment to delivery was recorded and classified into four ranges:
ISSN:1470-0328
1471-0528
1471-0528
DOI:10.1111/1471-0528.17151