Changes in Cerebral Blood Flow and Diffusion-Weighted Imaging Lesions After Intracerebral Hemorrhage

Intracerebral hemorrhage (ICH) is a common subtype of stroke and places a great burden on the family and society with a high mortality and disability rate and a poor prognosis. Many findings from imaging and pathologic studies have suggested that cerebral ischemic lesions visualized on diffusion-wei...

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Bibliographic Details
Published in:Translational stroke research 2022-10, Vol.13 (5), p.686-706
Main Authors: Yang, Jingfei, Jing, Jie, Chen, Shiling, Liu, Xia, Tang, Yingxin, Pan, Chao, Tang, Zhouping
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Blood pressure
Blood Pressure - physiology
Cardiology
Cerebral Hemorrhage - complications
Cerebrovascular Circulation
Diffusion Magnetic Resonance Imaging - methods
Edema
Hematoma
Hemorrhage
Humans
Hypertension
Ischemia
Magnetic resonance imaging
Mortality
Neurology
Neurosciences
Neurosurgery
Pathogenesis
Review Article
Stroke
Stroke - complications
Tomography
Vascular Surgery
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Summary:Intracerebral hemorrhage (ICH) is a common subtype of stroke and places a great burden on the family and society with a high mortality and disability rate and a poor prognosis. Many findings from imaging and pathologic studies have suggested that cerebral ischemic lesions visualized on diffusion-weighted imaging (DWI) in patients with ICH are not rare and are generally considered to be associated with poor outcome, increased risk of recurrent (ischemic and hemorrhagic) stroke, cognitive impairment, and death. In this review, we describe the changes in cerebral blood flow (CBF) and DWI lesions after ICH and discuss the risk factors and possible mechanisms related to the occurrence of DWI lesions, such as cerebral microangiopathy, cerebral atherosclerosis, aggressive early blood pressure lowering, hyperglycemia, and inflammatory response. We also point out that a better understanding of cerebral DWI lesions will be a key step toward potential therapeutic interventions to improve long-term recovery for patients with ICH.
ISSN:1868-4483
1868-601X
DOI:10.1007/s12975-022-00998-6