DNA/RNA sequencing using germanene nanoribbons via two dimensional molecular electronic spectroscopy: an ab initio study

Developing fast, reliable, and cost effective, yet practical DNA/RNA sequencing methods and devices is a must. In this regard, motivated by the recently introduced two-dimensional electronic molecular spectroscopy (2DMES) technique for molecular recognition, and the compatibility of 2D layers of gro...

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Bibliographic Details
Published in:Nanoscale 2022-03, Vol.14 (13), p.5147-5153
Main Authors: Reza Rezapour, M, Biel, Blanca
Format: Article
Language:English
Subjects:
Deoxyribonucleic acid
DNA
DNA - chemistry
Electronic devices
Electronics
Gene sequencing
Graphene
Mathematical analysis
Molecular spectroscopy
Nanoribbons
Nanotubes, Carbon
Ribonucleic acid
RNA
Selectivity
Sensitivity
Sequence Analysis, RNA
Spectrum Analysis
Two dimensional materials
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Summary:Developing fast, reliable, and cost effective, yet practical DNA/RNA sequencing methods and devices is a must. In this regard, motivated by the recently introduced two-dimensional electronic molecular spectroscopy (2DMES) technique for molecular recognition, and the compatibility of 2D layers of group IV elements with the current technology of manufacturing electronic devices, we investigate the capability of germanene nanoribbons (GeNRs) as a feasible, accurate, and ultra-fast sequencing device under the application of 2DMES. We show that by employing 2DMES, not only can GeNRs unambiguously distinguish different nucleobases to sequence DNA/RNA, they are also capable of recognizing methylated nucleobases that could be related to cancerous cell growth. Our calculations indicate that, compared to frequently used graphene layers, germanene provides more distinct adsorption energies for different nucleobases which implies its better ability to recognize various molecules unambiguously. By calculating the conductance sensitivity of the system for experimental purposes, we also show that the introduced sequencing device possesses a high sensitivity and selectivity characteristic. Thus, our proposed system would be a promising device for next-generation DNA sequencing technologies and would be realizable using the current protocols of fabricating electronic devices.
ISSN:2040-3364
2040-3372
DOI:10.1039/d1nr07336b