Boron compound administration; A novel agent in weight management: A systematic review and meta- analysis of animal studies

• Published in: Journal of trace elements in medicine and biology 2022-07, Vol.72, p.126969-126969, Article 126969
• Main Authors: Farrin, Nazila, Rezazadeh, Leila, Pourmoradian, Samira, Attari, Vahideh Ebrahimzadeh, Tutunchi, Helda, Zarezadeh, Meysam, Najafipour, Farzad, Ostadrahimi, Alireza
• Format: Article
• Language: English
• Subjects: Boron; Boron compound; Obesity; Weight
• ISSN: 0946-672X; 1878-3252
• DOI: 10.1016/j.jtemb.2022.126969

The worldwide growing trend of obesity across all ages has increased the number of researches on the obesity management and prevention. Boron is a potential essential trace element and there are some promising results on its weight lowering effect. Therefore, the present meta-analysis was aimed to assess the effect of boron on body weight. Databases including PubMed, Scopus, Cochrane Library, Embase, and Google Scholar were searched from 1995 until November 2021 using the definitive keywords. Searching was limited to articles with English language. Human studies were excluded in our analyses regarding their limited number and the heterogeneity of study designs. All of the relevant animal studies on rodents with weight changes as a primary outcome were included. The assessments of risk of bias and heterogeneity were conducted using the Cochrane Risk of Bias tool and I-square (I2) statistic respectively. According to our findings the overall effect of boron administration orally was significant decrease of body weight (WMD = −18.12 g 95% CI −23.28, −12.96; P