Immunomodulatory effects of curcumin in systemic autoimmune diseases

Systemic autoimmune diseases like rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus represent various autoimmune conditions identified by immune system dysregulation. The activation of immune cells, auto‐antigen outbreak, inflammation, and multi‐organ impairment is observed...

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Bibliographic Details
Published in:Phytotherapy research 2022-04, Vol.36 (4), p.1616-1632
Main Authors: Chamani, Sajjad, Moossavi, Maryam, Naghizadeh, Ali, Abbasifard, Mitra, Majeed, Muhammed, Johnston, Thomas P., Sahebkar, Amirhossein
Format: Article
Language:English
Subjects:
Antigens
Arthritis
Arthritis, Rheumatoid - metabolism
Autoimmune diseases
Autoimmune Diseases - drug therapy
Cell activation
Cell death
Cell proliferation
Chronic conditions
Complications
Curcumin
Curcumin - chemistry
Curcumin - pharmacology
Curcumin - therapeutic use
Ginger
Humans
Immune system
Immunology
Immunomodulation
immunomodulatory effect
Inflammation
Inflammation - complications
Lupus Erythematosus, Systemic - drug therapy
Microorganisms
Multiple sclerosis
Oxidative stress
Phenolic compounds
Phenols
Rheumatoid arthritis
systemic autoimmune diseases
Systemic lupus erythematosus
Tumors
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Summary:Systemic autoimmune diseases like rheumatoid arthritis, multiple sclerosis, and systemic lupus erythematosus represent various autoimmune conditions identified by immune system dysregulation. The activation of immune cells, auto‐antigen outbreak, inflammation, and multi‐organ impairment is observed in these disorders. The immune system is an essential complex network of cells and chemical mediators which defends the organism's integrity against foreign microorganisms, and its precise operation and stability are compulsory to avoid a wide range of medical complications. Curcumin is a phenolic ingredient extracted from turmeric and belongs to the Zingiberaceae, or ginger family. Curcumin has multiple functions, such as inhibiting inflammation, oxidative stress, tumor cell proliferation, cell death, and infection. Nevertheless, the immunomodulatory influence of curcumin on immunological reactions/processes remains mostly unknown. In the present narrative review, we sought to provide current information concerning the preclinical and clinical uses of curcumin in systemic autoimmune diseases.
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.7417