Management of Hypertrophic Cardiomyopathy in a Newborn with Dextro-Transposition of the Great Arteries

Impaired maternal glucose metabolism during pregnancy can have significant effects on the cardiovascular system of the developing fetus. Early in pregnancy the teratogenic effects may lead to structural heart defects, while later in gestation a form of hypertrophic cardiomyopathy can develop due to...

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Bibliographic Details
Published in:Pediatric cardiology 2022-04, Vol.43 (4), p.926-929
Main Authors: Bigelow, Amee M., Ball, Molly K., Galantowicz, Mark, Fernandez, Richard P., Gauntt, Jennifer, Texter, Karen M.
Format: Article
Language:English
Subjects:
Arteries
Cardiac Surgery
Cardiology
Cardiomyopathy, Hypertrophic
Case Report
Esmolol
Female
Glucose metabolism
Humans
Infant
Infant, Newborn
Medicine
Medicine & Public Health
Neonatology
Physiological aspects
Pregnancy
Retrospective Studies
Transposition of great arteries
Transposition of Great Vessels - diagnosis
Transposition of Great Vessels - surgery
Ultrasonography, Prenatal
Vascular Surgery
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Summary:Impaired maternal glucose metabolism during pregnancy can have significant effects on the cardiovascular system of the developing fetus. Early in pregnancy the teratogenic effects may lead to structural heart defects, while later in gestation a form of hypertrophic cardiomyopathy can develop due to overgrowth driven by fetal hyperinsulinism. We describe an infant with the uncommon combination of both dextro-transposition of the great arteries and hypertrophic cardiomyopathy. We emphasize the importance of a longitudinal multi-disciplinary approach, from fetal diagnosis to post-operative management, that allowed for an excellent outcome in this rare combination of severe cardiac malformations.
ISSN:0172-0643
1432-1971
DOI:10.1007/s00246-022-02874-4