Different patterns of sensory nerve involvement in chronic inflammatory demyelinating polyneuropathy subtypes

Introduction/Aims Among subtypes of chronic inflammatory demyelinating polyneuropathy (CIDP), different immune pathophysiologies have been proposed. In this study, sensory nerve conduction studies were compared among clinical subtypes to attempt to better understand the underlying pathophysiology. M...

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Bibliographic Details
Published in:Muscle & nerve 2022-08, Vol.66 (2), p.131-135
Main Authors: Shibuya, Kazumoto, Tsuneyama, Atsuko, Misawa, Sonoko, Suzuki, Yo‐ichi, Suichi, Tomoki, Kojima, Yuta, Nakamura, Keigo, Kano, Hiroki, Ohtani, Ryo, Aotsuka, Yuya, Morooka, Marie, Prado, Mario, Kuwabara, Satoshi
Format: Article
Language:English
Subjects:
Amplitudes
Antibodies
Blood
blood‐nerve barrier
chronic inflammatory demyelinating polyneuropathy
clinical subtypes
Demyelination
Glycoproteins
Immunoglobulin M
Inflammation
Median nerve
Myelin
Myelin-associated glycoprotein
Nerve conduction
nerve conduction study
Neuropathy
Patients
Polyneuropathy
sensory nerve action potential
Sensory neurons
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Summary:Introduction/Aims Among subtypes of chronic inflammatory demyelinating polyneuropathy (CIDP), different immune pathophysiologies have been proposed. In this study, sensory nerve conduction studies were compared among clinical subtypes to attempt to better understand the underlying pathophysiology. Methods A total of 138 patients with CIDP was classified into clinical subtypes: typical CIDP (N = 68), multifocal CIDP (N = 27), or other (N = 2). Patients with immunoglobulin M (IgM) neuropathy anti‐myelin‐associated glycoprotein neuropathy (MAG; N = 19) were also included as disease controls. Sensory nerve action potentials (SNAPs) were recorded in the median, ulnar, and superficial radial and sural nerves. Results SNAP amplitudes (P 
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.27530