Long-Term Clinical Impact of Contrast-Associated Acute Kidney Injury Following PCI: An ADAPT-DES Substudy

• Published in: JACC. Cardiovascular interventions 2022-04, Vol.15 (7), p.753-766
• Main Authors: Mohebi, Reza, Karimi Galougahi, Keyvan, Garcia, Javier Jas, Horst, Jennifer, Ben-Yehuda, Ori, Radhakrishnan, Jai, Chertow, Glenn M, Jeremias, Allen, Cohen, David J, Maehara, Akiko, Mintz, Gary S, Chen, Shmuel, Redfors, Björn, Leon, Martin B, Stuckey, Thomas D, Rinaldi, Michael J, Weisz, Giora, Witzenbichler, Bernhard, Kirtane, Ajay J, Mehran, Roxana, Dangas, George D, Stone, Gregg W, Ali, Ziad A
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - chemically induced; Acute Kidney Injury - diagnosis; Acute Kidney Injury - epidemiology; Contrast Media - adverse effects; Drug-Eluting Stents; Female; Hemorrhage - chemically induced; Humans; Male; Myocardial Infarction; Percutaneous Coronary Intervention - adverse effects; Prospective Studies; Renal Insufficiency, Chronic - complications; Risk Factors; Thrombosis - etiology; Treatment Outcome
• ISSN: 1876-7605
• DOI: 10.1016/j.jcin.2021.11.026

This study sought to determine correlates and consequences of contrast-associated acute kidney injury (CA-AKI) on clinical outcomes in patients with or without pre-existing chronic kidney disease (CKD). The incidence and impact of CA-AKI on clinical outcomes during contemporary percutaneous coronary intervention (PCI) are not fully defined. The ADAPT-DES (Assessment of Dual AntiPlatelet Therapy With Drug Eluting Stents) study was a prospective, multicenter registry of 8,582 patients treated with ≥1 drug-eluting stent(s). CA-AKI was defined as a post-PCI increase in serum creatinine of >0.5 mg/dL or a relative increase of ≥25% compared with pre-PCI. CKD was defined as estimated glomerular filtration rate