Estimation of bioactive peptide content of milk from different species using an in silico method

This study assessed the bioactive peptides content of milk from different species, including humans, camel, bovine, buffalo, donkey, sheep, goat, and horse. The highest and lowest concentrations of total digestion-resistant peptides were estimated in sheep and human milk. Donkey milk casein contains...

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Bibliographic Details
Published in:Amino acids 2023-10, Vol.55 (10), p.1261-1278
Main Authors: Parastouei, Karim, Jabbari, Masoumeh, Javanmardi, Fardin, Barati, Meisam, Mahmoudi, Yaser, Khalili-Moghadam, Sajad, Ahmadi, Houssein, Davoodi, Sayed Hossein, Mousavi Khaneghah, Amin
Format: Article
Language:English
Subjects:
Analytical Chemistry
Angiotensin
Antioxidants
ass milk
asses
Biochemical Engineering
Biochemistry
Biological activity
Biomedical and Life Sciences
Breast milk
buffaloes
camels
Cancer
Casein
cattle
Cholesterol
computer simulation
Enzymes
ewe milk
Food science
goat milk
Goats
horses
Immunomodulation
Life Sciences
Medical research
Milk
Neurobiology
Nutrition
Original Article
Peptides
Peptidyl-dipeptidase A
Proteins
Proteomics
Research centers
Sheep
Sheep's milk
species
Thrombosis
Whey
Whey protein
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Summary:This study assessed the bioactive peptides content of milk from different species, including humans, camel, bovine, buffalo, donkey, sheep, goat, and horse. The highest and lowest concentrations of total digestion-resistant peptides were estimated in sheep and human milk. Donkey milk casein contains a higher angiotensin-converting enzyme (ACE) inhibitory, dipeptidyl peptidase III (DPP-III) inhibitory, DPP-IV inhibitory, and antioxidant peptides. On the other hand, camel whey protein contains the highest ACE-inhibitory peptides. To discover BPs with immunomodulatory and cholesterol-lowering functions, goat milk casein and sheep milk whey protein can be considered, respectively.
ISSN:0939-4451
1438-2199
DOI:10.1007/s00726-022-03152-6