Improvement of sleep by resistant dextrin prebiotic in type 2 diabetic women coincides with attenuation of metabolic endotoxemia: involvement of gut–brain axis

BACKGROUND Resistant dextrin, as a prebiotic and functional food, may possess favorable effects in type 2 diabetes. This study was conducted to assess whether supplementation with resistant dextrin can improve sleep and quality of life in obese type 2 diabetic women. RESULTS In this randomized contr...

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Published in:Journal of the science of food and agriculture 2022-09, Vol.102 (12), p.5229-5237
Main Authors: Saleh‐Ghadimi, Sevda, Dehghan, Parvin, Sarmadi, Bahareh, Maleki, Parham
Format: Article
Language:English
Subjects:
Adrenocorticotropic hormone
Biomarkers
Blood
Blood glucose
Chemical activity
Cortisol
Dextrin
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Endotoxemia
Endotoxins
Fasting
Functional foods & nutraceuticals
Hemoglobin
HPA axis
Hypothalamic-pituitary-adrenal axis
Hypothalamus
Inflammation
Interleukin 6
Maltodextrin
metabolic endotoxemia
Metabolism
Pituitary
prebiotic
Prebiotics
Quality of life
Sleep
Tryptophan
Tumor necrosis factor
type 2 diabetes
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Summary:BACKGROUND Resistant dextrin, as a prebiotic and functional food, may possess favorable effects in type 2 diabetes. This study was conducted to assess whether supplementation with resistant dextrin can improve sleep and quality of life in obese type 2 diabetic women. RESULTS In this randomized controlled trial, female obese type 2 diabetic patients (n = 76) were randomly assigned into intervention group (n = 38) and placebo group (n = 38), and received 10 g day−1 of resistant dextrin or maltodextrin for a period of 8 weeks, respectively. Sleep quality and quality of life (QOL) were assessed by Pittsburgh Sleep Quality Index (PSQI) and SF‐36 health survey, respectively. Fasting blood samples were driven to measure serum bacterial endotoxin, fasting blood sugar, glycosylated hemoglobin (HbA1c), pro‐inflammatory/anti‐inflammatory biomarkers (IL‐18, IL‐6, IL‐10, TNF‐α), and biomarkers of hypothalamic‐pituitary‐adrenal (HPA) axis function [tryptophan (TRP), adrenocorticotropic hormone (ACTH), kynurenine (KYN), cortisol]. Supplementation with resistant dextrin improved sleep (P 
ISSN:0022-5142
1097-0010
DOI:10.1002/jsfa.11876