Chemical profiles and pharmacological insights of Anisomeles indica Kuntze: An experimental chemico-biological interaction

Anisomeles indica (L.) Kuntze is an ethnomedicinally important plant that has long been used in traditional medicine to treat a variety of ailments, including dyspepsia, abdominal pain, colic, allergies, inflammation, and rheumatic arthritis. However, the scientific framework underlying these medici...

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Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2022-05, Vol.149, p.112842-112842, Article 112842
Main Authors: Nasrin, Suaad, Islam, Mohammad Nazmul, Tayab, Mohammed Abu, Nasrin, Mst. Samima, Siddique, Md. Abu Bakar, Emran, Talha Bin, Reza, A.S.M. Ali
Format: Article
Language:English
Subjects:
Animals
Anisomeles indica
Anti-depression
Anti-inflammatory
Anti-Inflammatory Agents - therapeutic use
Antidepressive Agents - pharmacology
Antidiarrheal
Antidiarrheals - pharmacology
Castor Oil
Diarrhea - chemically induced
Diarrhea - drug therapy
Fibrinolytic Agents - pharmacology
Lamiaceae
MeOH-AI
Mice
Plant Extracts - therapeutic use
Thrombolytic
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Summary:Anisomeles indica (L.) Kuntze is an ethnomedicinally important plant that has long been used in traditional medicine to treat a variety of ailments, including dyspepsia, abdominal pain, colic, allergies, inflammation, and rheumatic arthritis. However, the scientific framework underlying these medicinal properties is not well known. This study aimed to investigate the antidepressive, antidiarrheal, thrombolytic, and anti-inflammatory potential of a methanol extract of A. indica (MeOH-AI). The potential bioactive compounds in the MeOH-AI were identified using gas chromatography-mass spectrometry (GC-MS), and antidepressant activities were evaluated using the tail suspension test (TST) and forced swim test (FST). Antidiarrheal effects were also assayed in castor oil-induced diarrhea and gastrointestinal motility studies. The anti-inflammatory activities were explored by examining the effects on protein inhibition and denaturation in heat- and hypotonic solution-induced hemolysis assays. The thrombolytic activity was evaluated using the clot lysis test in human blood. BIOVIA and Schrödinger Maestro (v11.1) were applied for docking analysis to determine binding interactions, and the absorption, distribution, metabolisms, excretion/toxicity (ADME/T) properties of bioactive compounds were explored using a web-based method. The GC-MS analysis of MeOH-AI revealed the presence of several bioactive compounds. MeOH-AI administration resulted in significant (p 
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2022.112842