The risk of dementia in patients with inflammatory bowel disease: a systematic review and meta-analysis

Background Growing evidence indicates that inflammatory bowel disease (IBD) and dementia share similar pathological mechanisms, but no consensus has yet emerged on the effect that IBD and dementia are associated. To explore such a possible correlation, we summarize herein the epidemiological evidenc...

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Bibliographic Details
Published in:International journal of colorectal disease 2022-04, Vol.37 (4), p.769-775
Main Authors: Zhang, Min-na, Shi, Yu-dan, Jiang, Hai-yin
Format: Article
Language:English
Subjects:
Alzheimer's disease
Care and treatment
Colitis
Confidence intervals
Dementia
Dementia - epidemiology
Dementia - etiology
Dementia disorders
Epidemiology
Gastroenterology
Gastrointestinal diseases
Hepatology
Humans
Inflammatory bowel disease
Inflammatory bowel diseases
Inflammatory Bowel Diseases - complications
Inflammatory Bowel Diseases - epidemiology
Internal Medicine
Intestine
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Meta-analysis
Neurodegenerative diseases
Odds Ratio
Proctology
Review
Risk Factors
Surgery
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Summary:Background Growing evidence indicates that inflammatory bowel disease (IBD) and dementia share similar pathological mechanisms, but no consensus has yet emerged on the effect that IBD and dementia are associated. To explore such a possible correlation, we summarize herein the epidemiological evidence. We subject relevant studies to meta-analysis. Methods We comprehensively searched Pubmed and Embase for relevant articles published to Dec 2021. The pooled risk ratio (RR) with the 95% confidence interval (CI) was used to estimate the effect; we calculated the generic inverse variance using a random-effects model. Results Seven studies involving 65,454 patients with dementia were included in the meta-analysis. The overall risk of dementia in IBD patients was significantly higher than that in the general population (risk ratio [RR], 1.35; 95% confidence interval [CI], 1.08–1.68; P  = 0.008). The results of subgroup analyses were consistent with the overall results. The risk of Alzheimer’s disease was higher in IBD patients (RR = 2.79, 95% CI = 1.1, 7.04; P  
ISSN:1432-1262
0179-1958
1432-1262
DOI:10.1007/s00384-022-04131-9