Research Updates: Relationship between Gingival Epithelial Intercellular Junctions and Periodontal Pathogenic Bacteria

Gingival epithelial barrier is the first line of defense of periodontal tissues against the invasion of pathogenic bacteria. The destruction of gingival epithelial barrier is closely related to the development of periodontal disease. Studies have shown that periodontal pathogenic bacteria and their...

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Bibliographic Details
Published in:Sichuan da xue xue bao. Journal of Sichuan University. Yi xue ban 2022-03, Vol.53 (2), p.214-219
Main Authors: Huang, Pei-Qing, Jia, Xiao-Yue, Zhao, Lei, Zhou, Xue-Dong, Xu, Xin
Format: Article
Language:Chinese
Subjects:
Animals
Bacteria
Bacterial Infections
Gingiva - pathology
Intercellular Junctions - metabolism
Periodontitis - metabolism
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Summary:Gingival epithelial barrier is the first line of defense of periodontal tissues against the invasion of pathogenic bacteria. The destruction of gingival epithelial barrier is closely related to the development of periodontal disease. Studies have shown that periodontal pathogenic bacteria and their inflammatory microenvironment can inhibit the expression of gingival epithelial junctional proteins via molecular mechanisms such as the downregulation of the expression of grainyhead-like protein family and the upregulation of the methylation level of gene promoter of epithelial connexin, and thus cause damage to the gingival epithelial barrier and the development of periodontitis. We herein reviewed the effects of bacteria and inflammatory factors induced by bacterial infection on gingival epithelial intercellular junctions and related mechanisms, and summarized the research progress on the relationship between gingival epithelial intercellular junctions and periodontal pathogenic bacteria in recent years. Most r
ISSN:1672-173X
DOI:10.12182/20220360201