Dermal extracellular matrix molecules in skin development, homeostasis, wound regeneration and diseases

The extracellular matrix (ECM) is a dynamic structure that surrounds and anchors cellular components in tissues. In addition to functioning as a structural scaffold for cellular components, ECMs also regulate diverse biological functions, including cell adhesion, proliferation, differentiation, migr...

Full description

Saved in:
Bibliographic Details
Published in:Seminars in cell & developmental biology 2022-08, Vol.128, p.137-144
Main Authors: Huang, Jinwen, Heng, Shujun, Zhang, Wenlu, Liu, Youxi, Xia, Tian, Ji, Chao, Zhang, Ling-juan
Format: Article
Language:English
Subjects:
Chronic wound
Dermal fibroblasts
Extracellular matrix
Keloid
Skin
Skin development
Wound healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The extracellular matrix (ECM) is a dynamic structure that surrounds and anchors cellular components in tissues. In addition to functioning as a structural scaffold for cellular components, ECMs also regulate diverse biological functions, including cell adhesion, proliferation, differentiation, migration, cell-cell interactions, and intracellular signaling events. Dermal fibroblasts (dFBs), the major cellular source of skin ECM, develop from a common embryonic precursor to the highly heterogeneous subpopulations during development and adulthood. Upon injury, dFBs migrate into wound granulation tissue and transdifferentiate into myofibroblasts, which play a critical role in wound contraction and dermal ECM regeneration and deposition. In this review, we describe the plasticity of dFBs during development and wound healing and how various dFB-derived ECM molecules, including collagen, proteoglycans, glycosaminoglycans, fibrillins and matricellular proteins are expressed and regulated, and in turn how these ECM molecules play a role in regulating the function of dFBs and immune cells. Finally, we describe how dysregulation of ECM matrix is associated the pathogenesis of wound healing related skin diseases, including chronic wounds and keloid.
ISSN:1084-9521
1096-3634
DOI:10.1016/j.semcdb.2022.02.027