Risk of ischaemic heart diseases and stroke in behçet disease: A systematic review and meta‐analysis

Background Behçet disease (BD) is a systemic vasculitis. In addition to the mucocutaneous lesions, the vascular injury of pathophysiology in BD is theoretically correlated with cardiovascular diseases. This study aimed to elucidate the association of BD with ischaemic heart diseases (IHDs) and strok...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical investigation 2022-08, Vol.52 (8), p.e13778-n/a
Main Authors: Chuang, Kai‐Wen, Chang, Hua‐Ching
Format: Article
Language:English
Subjects:
Autoimmune diseases
Behcet's syndrome
Behçet disease
Cardiovascular diseases
cerebrovascular accident
Complications
Confidence intervals
Coronary artery disease
Health risks
Heart diseases
Heterogeneity
ischaemic heart diseases
Ischemia
Meta-analysis
Neurological complications
Physicians
Stroke
Systemic vasculitis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Behçet disease (BD) is a systemic vasculitis. In addition to the mucocutaneous lesions, the vascular injury of pathophysiology in BD is theoretically correlated with cardiovascular diseases. This study aimed to elucidate the association of BD with ischaemic heart diseases (IHDs) and stroke. Methods A systematic search of PubMed, Embase, Web of Science and Cochrane Library databases was performed for all relevant observational studies from database inception until 10 July 2021. No language restriction was applied. A random‐effects model was used for meta‐analysis. Results A total of six observational studies consisting of three cohort studies, two cross‐sectional studies and one study with both study designs were adopted in the meta‐analysis. The numbers of patients with BD and healthy controls were 9,813 and 41,802, respectively. The pooled analysis demonstrated no significant association between BD and IHD. By contrast, we found that patients with BD had a significantly higher risk of stroke (adjusted hazard ratio, 2.083; 95% confidence interval, 1.339–3.240; p = 0.001) than healthy controls. We observed substantial heterogeneity across studies in few meta‐analyses, but no significant publication bias was detected in any of the meta‐analyses. Conclusions BD was significantly associated with stroke but not IHD. Physicians should be aware of possible vascular and neurological complications during care of patients with BD.
ISSN:0014-2972
1365-2362
DOI:10.1111/eci.13778