The metabolic signature of cardiovascular disease and arterial calcification in patients with chronic kidney disease

• Published in: Atherosclerosis 2022-06, Vol.350, p.109-118
• Main Authors: Sørensen, Ida MH, Bisgaard, Line S., Bjergfelt, Sasha S., Ballegaard, Ellen LF, Biering-Sørensen, Tor, Landler, Nino E., Pedersen, Tanja X., Kofoed, Klaus F., Lange, Theis, Feldt-Rasmussen, Bo, Bro, Susanne, Christoffersen, Christina
• Format: Article
• Language: English
• Subjects: Cardiovascular disease; CKD; Coronary calcification; Metabolomics; NMR
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2022.03.019

The relationship between chronic kidney disease (CKD) and cardiovascular events is well-established. Clinically recognised risk factors of cardiovascular disease cannot fully explain this association. The objective of the present cross-sectional study was to investigate associations between serum metabolites and prevalent cardiovascular disease, as well as subclinical cardiovascular disease measured as coronary artery calcium score (CACS) in patients with CKD. More than 200 preselected metabolites were quantified using nuclear magnetic resonance spectroscopy in 725 patients and 174 controls from the Copenhagen CKD Cohort. CACS was determined by computed tomography. Mean age of patients was 57.8 years, and 444 (61.3%) were men. Most of patients had hypercholesterolemia, and 133 (18.3%) had type 2 diabetes. Overall, 85 metabolites were significantly associated with prevalent cardiovascular disease in a model adjusted for eGFR, age, and sex, as well as Bonferroni correction for multiple testing (p