Prevalence and determinants of reticular pseudodrusen in the Russian Ural Eye and Medical Study

Purpose To assess the prevalence of reticular pseudodrusen (RPD) and their determinants. Methods The Population‐based Ural Eye and Medical Study conducted in Bashkortostan/Russia included 5899 participants aged 40+ years. Presence of RPDs was assessed on conventional colour fundus photographs, red‐f...

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Published in:Acta ophthalmologica (Oxford, England) England), 2022-12, Vol.100 (8), p.e1701-e1707
Main Authors: Bikbov, Mukharram M., Kazakbaeva, Gyulli M., Rakhimova, Ellina M., Rusakova, Iuliia A., Gilmanshin, Timur R., Zainullin, Rinat M., Panda‐Jonas, Songhomitra, Fakhretdinova, Albina A., Tuliakova, Azaliia M., Safiullina, Kamilia R., Bolshakova, Natalia I., Gizzatov, Ainur V., Ponomarev, Ildar P., Jonas, Jost B.
Format: Article
Language:English
Subjects:
Age
age‐related macular degeneration
Diabetes
Diabetes mellitus
epidemiology
Lymphocytes
macula
Macular degeneration
myopia
Population-based studies
population‐based study
reticular pseudodrusen
retina
subretinal drusenoid deposits
Ural Eye and Medical Study
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Summary:Purpose To assess the prevalence of reticular pseudodrusen (RPD) and their determinants. Methods The Population‐based Ural Eye and Medical Study conducted in Bashkortostan/Russia included 5899 participants aged 40+ years. Presence of RPDs was assessed on conventional colour fundus photographs, red‐free fundus images and optical coherence tomographic images. Results The study included 4914 (83.3%) individuals (mean age: 58.5 ± 10.5 years; range: 40–94 years). Using two age limits (>55 years and 40+ years) for the definitions of RPD and AMD (age‐related macular degeneration), RPD prevalence was 186/4914 (3.8%; 95% confidence interval (CI): 3.3, 4.3) and 246/4914 (5.0%, 95% CI: 4.4, 5.6), respectively, and the prevalence of any AMD without RPD was 182/4914 (3.7%: 95% CI: 3.2, 4.2) and 224/4914 (4.6%; 95% CI: 4.0, 5.1) respectively. Within the subgroup of early AMD, intermediate AMD and late AMD, RPD prevalence (age limit: 40+ years) was 55.1% (95% CI: 49.5, 60.8), 42.9% (95% CI: 33.8, 51.9) and 33.3% (95% CI: 16.4, 50.3) respectively. In multivariable analysis, higher RPD prevalence (age limit 40+ years) was associated with higher age (odds ratio (OR): 1.08; 95% CI: 1.07, 1.10; p 
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.15145