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Functional gold nanoparticles for diagnosis, treatment and prevention of thrombus

Thrombus treatment faces great challenges because of the difficulties in the early diagnosis and prevention, and targeted thrombolytic therapy. As a result, there is an urgent need to explore unique strategies to achieve the multiple targets of diagnosis, treatment, and prevention (DTP) by integrati...

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Bibliographic Details
Published in:Journal of controlled release 2022-05, Vol.345, p.572-585
Main Authors: Lv, Jiatong, Zhang, Lijing, Du, Wenzhen, Ling, Guixia, Zhang, Peng
Format: Article
Language:English
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Summary:Thrombus treatment faces great challenges because of the difficulties in the early diagnosis and prevention, and targeted thrombolytic therapy. As a result, there is an urgent need to explore unique strategies to achieve the multiple targets of diagnosis, treatment, and prevention (DTP) by integrating them into one nanosystem. Gold nanoparticles (AuNPs) as a classical type of inorganic nanomaterials with gold, is emergingly found effective in all stages of thrombus therapy due to the superiority of good optical properties, surface plasmon resonance, and biocompatibility. In this review, we focused on the multifunctional roles of AuNPs including visual diagnosis through optical imaging and biomarkers, thrombolytic therapy by photothermal effect and targeting delivery, and prevention of thrombosis in blood vessels and re-embolism of artificial im-plants. Especially, the application prospects of AuNPs and the optimization strategies of their nanocomposites are highlighted and discussed. It is anticipated to provide insight on the development of a more potential integrated platform for precise thrombus therapy. [Display omitted] •The early diagnosis and continuous monitoring of disease progression as well as effective treatment are vital for thrombus management.•The advantages of gold nanoparticles are attributed to physicochemical and biological properties.•Gold nanoparticles can be used for imaging, constructing sensors, delivering drugs, and acting as coatings on implants.•It provides a new direction to construct the integrated platform of diagnosis, treatment, and prevention of thrombosis with gold nanoparticles
ISSN:0168-3659
1873-4995
DOI:10.1016/j.jconrel.2022.03.044